This invention provides a
drug interaction prediction method based on a bidirectional cross-view
attention network, belonging to the field of
drug interaction prediction technology. The method first constructs a Morgan
fingerprint similarity view of the
drug, an original DDI view, and a multi-scale
diffusion view based on personalized
PageRank. Then, a graph convolutional network with shared weights is used to co-
encode the multiple views, generating a unified drug embedding representation. Finally, a bidirectional cross-view attention mechanism is used to achieve fine-grained interaction and alignment between the structural and attribute views, and interaction prediction is completed via a
multilayer perceptron. This invention effectively alleviates the sparsity problem of the DDI network through multi-scale topology enhancement and achieves complementary enhancement between views using bidirectional cross-view attention, significantly improving the accuracy and generalization ability of
drug interaction prediction. It can provide reliable
technical support for
drug development screening and clinical combined drug safety assessment.