The social networking interactive shopping system includes a portable wireless user interface for use by a store customer when shopping. A merchant server is provided, the server having market survey, advertising, promotions, security, social networking services, web server capability, a quantitative prediction modeling system predicting behavior of the customer, a predictive response marketing / advertising system that targets advertising messages to the customer based on a predicted customer response to the advertising messages, and payment application software. The merchant server is capable of wired or wireless communication with the portable wireless user interface. A database is provided, and can be stored on site or off site. The database includes information associated with items for sale at the store, and is in operable communication with the merchant server. Using the portable wireless user interface, the store customer can purchase user selected store items thereby obviating necessity for travel through a store check-out line.