Tannic acid preparation for treating burn, bedsore and diaper dermatitis and preparation method thereof

Abstract

The invention relates to a tannic acid preparation and a preparation method, and the tannic acid preparation is characterized by comprising, by weight, 2-30% of tannic acid, 40-75% of pharmaceutical adjuvants, and 20-50% of water. The pharmaceutical adjuvants used in the preparation comprise glycerin, monoglyceride stearate, beeswax, Vaseline, paraffin, tween, span, sodium bisulfate, ethylparaben, etc. The preparation method comprises the following steps: dissolving tannic acid by a little water or ethanol, heating to 55-85 DEG C to prepare an oil phase and a water phase, finally adding the water phase into the oil phase under uniform stirring, and performing condensation and split charging to obtain the tannic acid preparation. The preparation comprises paste agents (ointment, plaster), cream, emulsion, oil agents, water aqua, and the like, and the tannic acid content can be determined by a spectrophotometric method. The prepared tannic acid preparation conforms with medicine standards, and is suitable for the treatment of burn, bedsore and diaper dermatitis (neonatal red buttock) and the like.

Description

technical field [0001] The invention relates to a tannic acid preparation and a preparation method thereof, which meet the drug standards and are mainly used for treating burns, bedsores, diaper dermatitis and other diseases, and belong to the field of biomedicine. Background technique [0002] Tannin (Gallotannin, Tannin), also known as tannin, tannin, tannin, diplic acid, larch extract, gallin tannin, tannin, carnic acid, soft acid, molecular weight 1701.20, melting point: 210~215℃, slight special smell, strong astringent taste, darken when exposed to light and air, soluble in water, easily soluble in ethanol, acetone and glycerin, almost insoluble in ether, benzene, chloroform and petroleum ether. Tannic acid can precipitate proteins, and can form insoluble complexes with alkaloids, glycosides and heavy metals. Inflammation and other diseases, and gastric lavage with its solution has detoxification effect on dehydrated morphine, gentian, digitalis, lead, silver, copper, ...

AI Technical Summary

Problems solved by technology

[0003]Because tannic acid is a hydrolyzed tannin, a large amount of tannic acid absorbed into the body will damage the liver, so tannic acid is often made into external preparations for clinical use, such as tannic acid ointment It can precipitate protein, has astringent effect, hardens the skin, thereby protecting the mucous membrane, preventing excessive secretion and hemostasis, and can reduce local pain, reduce plasma exudation at the injured area, and prevent bacterial infection. It can be used to treat burns, eczema, Bed sores and diaper dermatitis (red buttocks of newborns), but the tannic acid ointment made by the previous method often has uneven dispersion of tannic acid, coarse particles, easy oxidative discoloration, matrix stratification is easy to occur during storage, and it is often applied in clinical use Unevenness reduces the effective contact area between tannic acid and the skin, which directly affects the effect of the drug