Lavage fluid comprising ascorbic acid or salt thereof, and purpose thereof
A technology of ascorbic acid and sodium ascorbate, applied in the medical field, can solve the problem that there is no very effective way to improve the healing of tendon and ligament injuries
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[0021] In one embodiment, a lavage solution is provided comprising
[0022] 15-50 mM ascorbic acid and / or pharmaceutically acceptable salts thereof; and
[0023] electrolyte,
[0024] The irrigation fluid has an osmolarity of 270 mOsm to 340 mOsm.
[0025] In another embodiment, there is provided a method of treating a tendon and / or ligament injury in an individual comprising irrigating said tendon and / or ligament with an irrigation solution disclosed herein.
[0026] In another embodiment, there is provided the use of ascorbic acid and / or pharmaceutically acceptable salts thereof in the preparation of a lavage solution for promoting healing of tendon and / or ligament injuries in individuals, wherein said ascorbic acid and / or pharmaceutically acceptable salts thereof Acceptable salts are present at a concentration of 15-50 mM in the irrigation fluid, and the irrigation fluid has an osmolarity of 270 mOsm to 340 mOsm.
[0027] In one embodiment, the lavage solutions disclosed...
Embodiment 1
[0047] The patella tendon window injury animal model of two-month-old male SD rats was used to prove the effect of the lavage fluid disclosed herein on the healing of acute tendon injuries. In this example, in the experimental group, the lavage solution used contained 15 mM, 50 mM and 150 mM sodium ascorbate respectively, while the control group used normal saline. The lavage fluids used in the three experimental groups were:
[0048] LD vitC: Contains 3mg / ml (or about 15mM) sodium ascorbate, 7.8g / L NaCl;
[0049] MD vitC: containing 10mg / ml (or about 50mM), 5.8g / L NaCl;
[0050] HD vitC: Contains only 15mg / ml (or about 151mM) sodium ascorbate.
[0051] After the animal was sacrificed on the 42nd day, the effect of the lavage fluid disclosed herein on the mechanical strength of the tissue healing was detected by a biomechanical test, and the results were as follows: figure 1 and figure 2 shown. Experiments have proved that the initial application of the lavage fluid disc...
Embodiment 2
[0055] In the animal experiment, an anterior cruciate ligament (ACL) reconstruction model of three-year-old male SD rats was used to demonstrate the effect of the lavage fluid disclosed herein on tendon injury healing. In the experimental group, the lavage solution used contained 15mM, 50mM and 150mM sodium ascorbate respectively, while the control group used normal saline. The lavage fluids used in the three experimental groups were:
[0056] LD vitC: containing 3mg / ml (or 15mM) sodium ascorbate, 7.8g / L NaCl
[0057] MD vitC: containing 10mg / ml (or 50mM), 5.8g / L NaCl
[0058] HD vitC: Contains only 15mg / ml (or 151mM) sodium ascorbate.
[0059] After the animal was sacrificed on the 42nd day, the static front and rear (A-P) knee laxity and knee strength were detected by biomechanical test, the results were as follows: image 3 and Figure 4 shown. Experiments have shown that initiating the application of the lavage solution disclosed herein is beneficial during surgery an...
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