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Method to measure structures of human brain

A technique for measuring shaft and structural parameters, applied in the direction of using magnetic variable measurement, magnetic resonance measurement, measurement using nuclear magnetic resonance imaging system, etc.

Inactive Publication Date: 2013-05-08
SIEMENS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it has been shown that this technique can only be used limitedly to predict Alzheimer's disease
Here, the main problem is that volumetric alterations that can be demonstrated with the usual resolution are already accompanied by significant disease development

Method used

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  • Method to measure structures of human brain
  • Method to measure structures of human brain
  • Method to measure structures of human brain

Examples

Experimental program
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Embodiment Construction

[0026] figure 1 A flow chart of the method according to the invention is shown in an exemplary embodiment. In step 1 , a magnetic resonance pre-examination, in particular an overview of the brain to be examined, is initially recorded. Conventional techniques for recording such overview images can be used here.

[0027] During the magnetic resonance pre-examination, the hippocampal region in the brain is automatically segmented and localized in step 2 using segmentation algorithms known from the prior art.

[0028] Since the position and state of the hippocampus is now known, in step 3 several measurement axes are automatically arranged through the hippocampus and thus through the entire brain, which are to be measured underneath. However, it is also conceivable here to determine these measuring axes manually by an operator.

[0029] figure 2 A possible selection of measuring axes 4 a - 4 g that covers the space as well as possible and provides information in as many direc...

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Abstract

In a method to measure characteristic structure sizes of the human brain, which structure sizes can be used as biomarkers for a diagnosis of Alzheimer's, using a magnetic resonance device, manual and / or automatic localization of the hippocampus takes place in a preliminary magnetic resonance acquisition, followed by selection of at least one measurement axis that proceeds through the hippocampus. For each selected measurement axis, magnetic resonance data are acquired for a longitudinal, in particular rod-shaped, acquisition region proceeding along the measurement axis. Determination of the spatially resolved structure sizes is implemented from the magnetic resonance data.

Description

technical field [0001] The invention relates to a method for measuring, using a magnetic resonance apparatus, a structural parameter specific to the human brain that can be used as a biomarker for the diagnosis of Alzheimer's disease. The invention also relates to a magnetic resonance device. Background technique [0002] Alzheimer's disease is a recurrent dementia in developed societies. The development of pharmacy is currently expected to produce drugs or medicines that can obviously delay the development of diseases. Diagnostically this means that the onset of changes in the human brain must be detected as early as possible so that the loss of cognitive abilities can be preserved as minimally as possible. There is usually a period of several years between so-called "mild cognitive impairment" (MCI, CDR0.5) and severe clinical symptoms (CDR3). The earlier the disease is identified, the more brain function can be saved. [0003] For the diagnosis of Alzheimer's disease,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/055G01R33/56
CPCA61B5/4088A61B5/055A61B5/1075A61B5/7225A61B5/0042A61B5/0037
Inventor B.海斯曼S.施米特
Owner SIEMENS AG
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