A kind of preparation method of gold magnetic particles

A technology of gold magnetic particles and a synthesis method, which is applied in the direction of the magnetism of inorganic materials, can solve the problems affecting the uniformity of gold magnetic particles, the identity of functional groups on the dispersed surface, the cumbersome gold coating method, and the impact on downstream applications, etc., to achieve Ensure the effect of dispersion and uniformity, uniform particle size and strong controllability

Active Publication Date: 2015-12-02
XIAN GOLDMAG NANOBIOTECH
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  • Abstract
  • Description
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Problems solved by technology

Peng Li used the Frens method to determine Fe 3 o 4 The particles are the core, and the Fe dispersed in the aqueous phase is prepared 3 o 4 Au nanocomposite particles, but the particle size is not uniform and the dispersion is poor
The patent (CN: 200910113126.9) uses PEI to modify the magnetic particles, then puts a small amount of colloid into the seed and then uses hydroxylamine hydrochloride to reduce the gold coating layer. Amines are used as reducing agents to coat gold, but the functional groups on the surface of the prepared gold magnetic particles are not uniform and affect downstream applications
This leads to the poor compatibility of magnetic particle modification in the reducing agent system, which affects the uniformity, dispersion and identity of surface functional groups of gold magnetic particles.

Method used

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  • A kind of preparation method of gold magnetic particles
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  • A kind of preparation method of gold magnetic particles

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preparation example Construction

[0032] The preparation method of the present invention mainly comprises the following links:

[0033] Step 1) Fe modified by citric acid 3 o 4 Nanoparticles

[0034] The method of co-precipitation synthesis is prepared to obtain Fe 3 o 4 Add the aqueous nanoparticle suspension into the reactor, stir and ventilate nitrogen, then add citric acid aqueous solution, and react at a certain temperature, cool to room temperature after the reaction, magnetically separate, wash, redisperse in ultrapure water, As a magnetic nanoparticle stock solution;

[0035] Step 2) Synthesis of gold magnetic particles

[0036] (a) Preparation and pretreatment of the reducing agent solution: dissolving the reducing agent in water to form an aqueous reducing agent solution, and adjusting its pH value to 8-10.

[0037] (b) Preparation of gold magnetic particles: Mix a certain volume of magnetic nanoparticles with a reducing agent solution, and disperse evenly by ultrasonic waves. When the reducing a...

Embodiment 1

[0041] Step 1) Fe modified by citric acid 3 o 4 Nanoparticles

[0042] Take 100ml co-precipitation synthesis method to prepare Fe 3 o 4 Add the nanoparticle aqueous phase suspension into the reactor, stir and blow nitrogen, then add 10ml of 1% citric acid aqueous solution, and react at 70°C for 10 minutes, finish the reaction and cool to room temperature, magnetically separate, wash, and redisperse in Ultrapure water, as a magnetic nanoparticle stock solution;

[0043] Step 2) Synthesis of gold magnetic particles

[0044] (a) Preparation and pretreatment of reducing agent solution: Dissolve 0.0017g of sodium citrate in 33.20ml of water to form an aqueous reducing agent solution, and adjust its pH value to 9.

[0045] (b) Preparation of gold magnetic particles: Mix 2.015ml of magnetic nanoparticles with a concentration of 6.2mg / ml and 4ml of sodium citrate solution, and disperse evenly by ultrasonic waves. When the sodium citrate solution is heated to boiling, the magnetic...

Embodiment 2

[0047] Step 1) Fe modified by citric acid 3 o 4 Nanoparticles

[0048] Take 100ml co-precipitation synthesis method to prepare Fe 3 o 4 Add the nanoparticle aqueous phase suspension into the reactor, stir and blow nitrogen, then add 10ml of 1% citric acid aqueous solution, and react at 70°C for 10 minutes, finish the reaction and cool to room temperature, magnetically separate, wash, and redisperse in Ultrapure water, as a magnetic nanoparticle stock solution;

[0049] Step 2) Synthesis of gold magnetic particles

[0050] (a) Preparation and pretreatment of reducing agent solution: Dissolve 0.0017g of sodium citrate in 33.20ml of water to form an aqueous reducing agent solution, and adjust its pH value to 9.

[0051] (b) Preparation of gold magnetic particles: Mix 2.015ml of magnetic nanoparticles with a concentration of 6.2mg / ml and 4ml of sodium citrate solution, and disperse evenly by ultrasonic waves. When the sodium citrate solution is heated to boiling, the magnetic...

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Abstract

The invention provides a novel preparation method for gold magnetic particles. A series of gold magnetic particles with different colors and different sizes can be prepared by adjusting concentration of solution, and the obtained gold magnetic particles have good dispersity, stability and magnetic properties in water solution and can be applied to a plurality of fields such as catalyzing and magnetic quantitative detection. Fe3O4 nano particle crude products obtained in a coprecipitation synthesis method serve as reacting raw materials, first citric acid is adopted to modify magnetic nano particles, and after magnetic separation, the obtained Fe3O4 nano particles are dispersed in ultrapure water to be adjusted to be neutral; then chloroauric acid solution is adopted, polybasic carboxylic acid or salt containing polybasic carboxyl acid radical ions serves as a reducing agent to enable Au3+ to be reduced on the surfaces of the Fe3O4 nano particles to be Au0, and the gold magnetic particles are prepared. The novel preparation method has the advantages of being simple, easy to operate and controllable.

Description

technical field [0001] The invention relates to a preparation method of gold magnetic particles. Background technique [0002] Gold magnetic particles are a new type of material developed in recent years, which can be rapidly separated from other components under the action of an external magnetic field, or undergo directional movement induced by a magnetic field. In addition, the gold magnetic particles are endowed with dual characteristics of colloidal gold and magnetic materials. Not only the colloidal gold is biocompatible, but also the optical absorption tunable characteristics in a wide range of wavelengths can be realized by adjusting the thickness of the gold shell. Such composite nanomaterials are widely used in catalysis, sensors, substrates for surface-enhanced Raman scattering, photonic bandgap materials, multifunctional materials, biomedicine and other fields, and are one of the hotspots in current nanoparticle research. [0003] There are many methods for synt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24H01F1/11
Inventor 彭明丽靳艳艳崔亚丽田志敏邢艳唐丽娜
Owner XIAN GOLDMAG NANOBIOTECH
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