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Method for detecting lethal system and use thereof

A micrometric, cell line technology, applied in the field of detection of lethal systems and their uses, can solve problems such as no success

Active Publication Date: 2015-12-16
杨孝德
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no successful precedent for a method that uses the expression of intracellular molecules to assess and judge the risk of patients suffering from incurable diseases

Method used

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  • Method for detecting lethal system and use thereof
  • Method for detecting lethal system and use thereof
  • Method for detecting lethal system and use thereof

Examples

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example 1

[0049] Example 1. Cancer patients with NFA + Tumor-EMT-stroma-BMC lethal system, even after surgical cure, still has a poor prognosis

[0050] This example uses the coevolutionary state and NFA expression as an experimental model. In samples from patients with poor prognosis breast cancer, there will be a single individual NFA+ / vimentin+ / S100A4 / FSP-1+ large round metastatic MTC( figure 1 A), especially in distant tumor stroma ( figure 1 B) and perivascular space ( figure 1 C) and the intravascular area ( figure 1 D) aggregated, which may provide evidence for the critical role of NFA in EMT induction and breast cancer development. It is evident that the mesenchymal state via EMT imparts metastatic and invasive properties to cancer cells, induces cancer stem cell properties, prevents apoptosis and senescence, and contributes to immunity against chemotherapy, immunotherapy, and targeted therapy Inhibition and multi-resistance. Therefore, the mesenchymal state of cancer cell...

example 2

[0051]Example 2. The NFA lethal system as a potential target for cancer patient prognosis

[0052] In a large cohort study, more than 50% of breast cancer patients with poor prognosis (44 / 74) showed the NFA lethal system as described above. On the other hand, if breast cancer patients have NFA lethal system, none of them will have a good prognosis after treatment, and in the group of 67 breast cancer patients with good prognosis, no patients showed NFA lethal system. Likewise, -56% (44 / 78) of poor prognosis lung cancer patients showed NFA lethal system, and in a population of 53 good prognosis lung cancer patients, no false positive cases could be detected. Likewise, ~67% (61 / 91) of poor prognosis GI cancer patients showed NFA lethal system, and after treatment, all had poor prognosis; in a total of 94 good prognosis lung cancer patients , false positive cases could not be detected after treatment. Overall, in a total of 457 cancer patients, including 214 cases with good pro...

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Abstract

The present invention provides a method for detecting whether a lethal system exists in a patient by using the expression of the marker nuclear factor A (NFA). In another aspect, the present invention provides a method for predicting the potential of metastasis and whether it is at risk of developing metastasis, and the method is used to detect the prognosis of the patient.

Description

technical field [0001] The present invention facilitates the identification and detection of cancer micrometastases; and methods, kits and uses thereof for predicting the prognosis of different types of cancer patients regardless of the etiological origin of the cancer. The present invention further provides a method and kit to help predict whether a patient has a disease with metastatic potential and is at risk for systemic metastases. Background technique [0002] Most deaths are from cancer, which is due to metastatic lesions. However, after nearly 2 million papers in cancer research over the past 50 years, we have yet to understand when and how cancer metastasis occurs. It is now well established that metastasis is the end product of the developmental process between cancer cells and their microenvironment; and that systemic cancer development may result from parallel development of the primary tumor and from early disseminated epithelial and stromal cells. Metastasis ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/48G01N33/573
CPCG01N33/5044G01N33/574G01N2800/50G01N2800/56
Inventor 杨孝德
Owner 杨孝德
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