Multi-sample stage allowing for automatic movement of inverted microscopes

An inverted microscope and automatic movement technology, which is applied in the field of biological science experiments, can solve the problems of inconvenient replacement and the inability to set up multiple sample cells at the same time, achieve precise positioning, simplify the process of replacement and focusing, and achieve the effect of small size

Inactive Publication Date: 2013-08-07
INST OF PHYSICS - CHINESE ACAD OF SCI
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  • Abstract
  • Description
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Problems solved by technology

[0005] The purpose of the present invention is to overcome the defect that the existing inverted microscope stage is not convenient for the sample to be observed to be replaced and focused in...

Method used

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  • Multi-sample stage allowing for automatic movement of inverted microscopes
  • Multi-sample stage allowing for automatic movement of inverted microscopes

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Embodiment Construction

[0020] The multi-sample stage for the automatic movement of the inverted microscope includes a sample stage base 1, an objective lens mounting seat 2 is provided in the center of the sample stage base 1, and an objective lens 3 is provided below the objective lens mounting seat 2, and it is characterized in that: on the sample stage base 1 On both sides of the objective lens mount 2 are respectively provided with a screw rod support 4, the screw rod 5 is arranged on the two screw rod supports through a shaft coupling 6, and the shaft coupling 6 is connected with the driving motor 7; There are slide rails 8, and the slide rails 8 are provided with a sample tank mobile rack 9, and the top of the sample tank mobile rack 9 is screwed on the screw rod 5 through a joint 10, and when the screw rod 5 rotates, the sample tank mobile rack 9 will be driven on the slide. Move left and right on the rail 8; on the base of the sample table 1, there is a sample tank fixing frame 11, on which t...

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Abstract

The invention relates to a multi-sample stage allowing for automatic movement of inverted microscopes. The multi-sample stage comprises a sample stage base and an objective lens. Screw supports are arranged on the sample stage base. A screw is arranged on the two screw supports through a coupling. The coupling is connected with a drive motor. A slide is arranged on the sample stage base. A sample cell moving rack is arranged on the slide. The top of the sample cell moving rack is screwed to the screw through a connector. A sample cell fixed rack is arranged on the sample stage base and is provided with a sample cell. The upper surface of the sample cell is made of a quartz glass slide, and the lower surface of the sample cell is made of a cover glass. The periphery of each of the quartz glass slide and the cover glass is sealed with epoxy resin. Space between the quartz slide glass and the cover glass is divided into a plurality of independent sample channels. The quartz glass slide is provided with through holes corresponding to the independent sample channels. The through holes are connected with an automatic sample feeder through sample guide tubes. The multi-sample stage is applicable to various inverted microscopes, is small in size, handy, flexible, and simple and fast to operate, and is an effective tool for the biological single-molecular study.

Description

technical field [0001] The invention belongs to the field of biological science experiments, and is a device for detecting and manipulating single molecules, in particular a multi-sample stage for automatic movement of an inverted microscope. Background technique [0002] Single-molecule technology refers to the real-time dynamic detection of the behavior of biological macromolecules (including conformational changes, interactions, mutual recognition, etc.) Single-molecule technology has the advantages of being direct, accurate, and real-time. By observing the behavior of single molecules such as single enzyme molecules and RNA / DNA molecules, we can study the elastic properties of nucleic acid molecules and the structural changes caused by external forces; The study of the special local environment of a single molecule, the fluctuation of molecules, the flexibility and motion of biomacromolecules has created favorable conditions and played a huge role in promoting the devel...

Claims

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Application Information

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IPC IPC(8): G02B21/34G02B21/26
Inventor 徐雅楠翟永亮窦硕星
Owner INST OF PHYSICS - CHINESE ACAD OF SCI
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