Medicinal composition for treating diabetes, and its application
A diabetes drug and composition technology, applied in the field of diabetes treatment drugs, can solve the problems of stimulating the digestive tract, effective dose difference, anorexia, etc., and achieve the effect of improving the use effect, reducing risk, and reducing the concentration of the drug
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Embodiment 1
[0019] Example 1 Preparation of diabetic mouse model
[0020] Streptozotocin (STZ) can damage pancreatic islet cells, resulting in insufficient insulin secretion and hyperglycemia, leading to type 1 diabetes. We used the method of intraperitoneal injection of STZ (50mg / kg) to establish a type Ⅰ diabetes model, selected 8-week-old male C57 mice, injected STZ intraperitoneally for five consecutive days, and tested blood glucose one week later. The mice with blood glucose greater than 11.1mmol / L were returned to The diabetic mouse model prepared for the diabetes group (Wld(S) protects against peripheral neuropathy and retinopathy in an experimental model of diabetes in mice. Diabetologia. 2011,54(9):2440-50.) was used for subsequent experiments.
Embodiment 2
[0021] Example 2 Glycine and metformin compound synergy experiment
[0022] The experiment was divided into five groups: negative control group (normal mice + normal saline), model group (STZ + normal saline), metformin hydrochloride group (STZ + Metformin 150mg / kg), glycine group (STZ + Glycine 600mg / kg), glycine And metformin compound group (STZ+Metformin150mg / kg +Glycine600mg / kg), intraperitoneal injection of drugs for a week, detection of changes in blood sugar:
[0023] Administration method: intraperitoneal injection of drug for one week;
[0024] Detection index: take it as the main index, and observe the clinical manifestations of animals at the same time.
[0025] The effect of each prescription on the blood sugar of diabetic mice is shown in figure 1 . After one-way analysis of variance by LSD method, the results showed that there were statistical differences among the groups (p<0.05). Compared with the model group, glycine and metformin hydrochloride compound gr...
Embodiment 3
[0026] Example 3 Compound synergistic experiment of different ratios of glycine and metformin
[0027] The experiment was divided into five groups: negative control group (normal mice + normal saline), model group (group I, STZ + normal saline), glycine and metformin compound 1:2 group (group II, STZ + Metformin100mg / kg + Glycine200mg / kg ), glycine and metformin compound 1:3 group (group III, STZ+Metformin100mg / kg +Glycine300mg / kg), glycine and metformin compound 1:4 group (group IV, STZ+Metformin100mg / kg+Glycine400mg / kg), intraperitoneal injection Drugs for a week, detect changes in blood sugar:
[0028] Administration method: intraperitoneal injection of drug for one week;
[0029] Detection index: take it as the main index, and observe the clinical manifestations of animals at the same time.
[0030] The effect of each prescription on the blood sugar of diabetic mice is shown in figure 2 . Compared with the model group, both the glycine and metformin hydrochloride comp...
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