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Furazolidone tablet preparation method
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A furazolidone tablet and furazolidone technology are applied in the field of medicine to achieve the effects of convenient operation, improved bioavailability, and high dissolution rate in vitro
Active Publication Date: 2013-09-04
YUNNAN PHYTOPHARML
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Problems solved by technology
The quality standard of the 2010 edition of the National Pharmacopoeia has increased the in vitro dissolution rate of this variety to 70%, while the in vitro dissolution rate of tablets obtained by the existing domestic production process of this variety is mostly 50-60%, which is far below the qualified limit of the quality standard requirements
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Embodiment 1
[0024] Get furazolidone, copovidone, croscarmellose sodium and sieve 80 mesh, and silicon dioxide sieve 120 mesh. Dissolve 2.2 g of povidone and 1 g of propylene glycol in water to prepare a 1% adhesive solution. Mix 4 g of copovidone and 1.8 g of croscarmellose sodium evenly, and then mix evenly with 100 g of furazolidone in an equal amount incremental method. Add the aforementioned binder solution to make a soft material, granulate with 30 mesh, dry at 65°C, granulate with 30 mesh, add 1.0 g of silicon dioxide, mix evenly, and press into tablets according to the weight of 0.110 g. Disintegrate for 5 minutes, and dissolve 88%.
Embodiment 2
[0026] Furazolidone, dextrin, hydroxypropyl cellulose and povidone were sieved to 80 mesh, and silicon dioxide, magnesium stearate and talcum powder were sieved to 120 mesh. Dissolve 14g of starch, 0.8g of macrogol glyceride laurate, and 3g of sodium lauryl sulfate in hot water to prepare a 20% binder solution. Mix 3.2 g of dextrin, 4 g of hydroxypropyl cellulose, and 4 g of povidone evenly, and then mix evenly with 100 g of furazolidone by equal addition method. Add the aforementioned binder solution to make soft material, granulate with 16 mesh, granulate with 18 mesh after drying at 70°C, add 2g of silicon dioxide, 2g of magnesium stearate and 2g of talc powder, mix evenly, and press the tablet according to the weight of 0.135g. have to. It disintegrates for 5 minutes and dissolves 82%.
Embodiment 3
[0028] Furazolidone, hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone and cyclodextrin were sieved to 80 mesh, and magnesium stearate and silicon dioxide were sieved to 120 mesh. Dissolve 10 g of hydroxypropyl methylcellulose and 3 g of sodium lauryl sulfate in water to prepare a 2% binder solution. Mix 8 g of hydroxypropyl cellulose, 10 g of cross-linked polyvinylpyrrolidone, and 10 g of cyclodextrin evenly, and then mix evenly with 100 g of furazolidone by the method of equal addition. Add the aforementioned binder solution to make a soft material, granulate with 12 mesh, dry at 70°C and granulate with 30 mesh, add 2.0g of magnesium stearate and 2.0g of silicon dioxide, mix evenly, and press into tablets according to the weight of 0.145g. Disintegrate for 5 minutes, and dissolve 85%.
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Abstract
The present invention relates to a furazolidone tablet preparation method, which is performed according to the following steps: taking furazolidone, a binder and a solubilizer, screening, respectively screening a lubricant and a flow aid with a 80-120 mesh sieve, adding water or an alcohol to the partial binder having the content of more than or equal to 28% of the total amount of the binder and the partial solubilizer having the content of more than or equal to 14% of the total amount of the solubilizer to prepare a binder solution with a mass concentration of 1-30%, uniformly mixing the remaining binder and the remaining solubilizer, uniformly mixing with the furazolidone according to an equivalent gradual increase method, adding the binder solution to prepare a soft material, carrying out 12-30 mesh pelletization, drying at a temperature of less than 70 DEG C, carrying out 12-30 mesh granulating, adding a lubricant and a flow aid, uniformly mixing, and tabletting to obtain the finished product. According to the present invention, the reasonable process operation sequence is adopted, the part of the solubilizer is adopted to increase furazolidone hydrophilicity, and the part of the solubilizer is adopted to promote furazolidone self-emulsifying and increase solubility in water so as to improve a dissolution rate and increase bioavailability.
Description
Technical field [0001] The invention involves the field of pharmaceutical technology, which is specifically a method for preparing amurazolidone tablets. Background technique [0002] Aurazolidone tablets, alias, is the psychic tablet.The chemical name is 3- (5-3 pupaminel) -2-vulgarizone.This product is a nitro -amura antibacterial drug.It has a certain antibacterial effect on Gram -positive and negative bacteria, including Salmonella, Chiga, E. colon, pneumonia, Crastacus, Enterobacteria, Golden Portuga, PeridococcusThe genus of the Condois, Candaculis, and Modern bacteria, etc., also have activity to caterpillar and Jiadi whip caterpillars under a certain concentration.Its mechanism is to interfere with bacterial oxidation enzymes to block the normal metabolism of bacteria. [0003] Aurazolone is slightly soluble in water and ethanol, slightly soluble in chloroform, insoluble in ether, and is easily soluble in di metamimam and nitro methane.When the pH value is 6, the solubil...
Claims
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Application Information
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