32 results about "Furazolidonum" patented technology

The present invention relates to a furazolidone tablet preparation method, which is performed according to the following steps: taking furazolidone, a binder and a solubilizer, screening, respectively screening a lubricant and a flow aid with a 80-120 mesh sieve, adding water or an alcohol to the partial binder having the content of more than or equal to 28% of the total amount of the binder and the partial solubilizer having the content of more than or equal to 14% of the total amount of the solubilizer to prepare a binder solution with a mass concentration of 1-30%, uniformly mixing the remaining binder and the remaining solubilizer, uniformly mixing with the furazolidone according to an equivalent gradual increase method, adding the binder solution to prepare a soft material, carrying out 12-30 mesh pelletization, drying at a temperature of less than 70 DEG C, carrying out 12-30 mesh granulating, adding a lubricant and a flow aid, uniformly mixing, and tabletting to obtain the finished product. According to the present invention, the reasonable process operation sequence is adopted, the part of the solubilizer is adopted to increase furazolidone hydrophilicity, and the part of the solubilizer is adopted to promote furazolidone self-emulsifying and increase solubility in water so as to improve a dissolution rate and increase bioavailability.

The invention relates to a medicine for treating hepatomegaly. The medicine for treating the hepatomegaly comprises the medicinal raw materials as follows: 7g of gastrodia elata, 7g of Rhizoma Pinelliae, 7g of taro pulp, 5g of pharbitis seed, 3g of garden burnet, 3g of Astragalus mongholicus, 5g of fructus psoraleae and 5g of date kernel; and the medicine for treating the hepatomegaly also comprises the components as follows: 20 furazolidone tablets, 20 terramycin tablets, 15 compound acetylsalicylic acid tablets, 2 belladonna tablets and 5 flu-treating capsules. The medicine for treating the hepatomegaly has the advantages that the medicine for treating the hepatomegaly can treat hepatomegaly caused by various reasons, has an obvious therapeutic effect and takes effect quickly; and through combined therapy of the traditional Chinese medicine and Western medicine, the used Western medicinal raw materials are finished medicines sold in the market, with wide source, easy obtainment and low price, so that the medicine for treating the hepatomegaly is low in cost and high in cost performance.

The invention provides a method for detecting furazolidone by electrochemiluminescence method, which uses aminated manganese dioxide / nano gold / modified SnO doped with fluorine 2 Transparent film (FTO) (NH‑MnO 2 / NAu / FTO) conductive glass as the working electrode, the Ag / AgCl electrode as the reference electrode, and the platinum electrode as the auxiliary electrode to form a three-electrode system; using the electrostatic interaction between amino groups and negatively charged gold nanoparticles, the composite material It is fixed on FTO, and furazolidone is adsorbed, and furazolidone is detected by electrochemiluminescence. The detection range of this method is 1.0×10 ‑8 mol / L‑1.0×10 ‑ 5 mol / L, the lowest detection limit is 6.6×10 ‑9 mol / L. The sensor prepared by the invention has the advantages of low cost, high sensitivity, simple operation and good selectivity for detecting furazolidone.

The invention discloses a furazolidone AOZ-D4 synthesis method, which comprises: 1) carrying out a reaction on deuterated acetic acid and bromine in the presence of TFAA to obtain deuterated bromoacetic acid; 2) carrying out a reaction on the deuterated bromoacetic acid and oxalyl chloride (or SOCl2) in DMF, adding benzyl alcohol, and continuously carrying out a reaction to obtain deuterated benzyl bromoacetate; 3) adding the deuterated benzyl bromoacetate into the THF solution of NaBD4, and carrying out a reaction to obtain deuterated bromoethanol; 4) dissolving hydrazine hydrate in dehydrated alcohol, adding NaOH, stirring, adding the deuterated bromoethanol, and carrying out a reaction to obtain deuterated 2-hydroxyethyl hydrazine; and 5) carrying out a reaction on the deuterated 2-hydroxyethyl hydrazine and dimethyl carbonate in the presence of an alkali to synthesize furazolidone AOZ-D4.

The invention relates to a low-carbon mixed organic acid used for oil well plug removal, a preparation method and an application thereof. The low-carbon mixed organic acid is prepared from the following raw materials by mass percent: 4-6 % of fatty alcohol, 2.4-2.5 % of ethylene oxide, 4-6 % of alkylbenzenesulfonate, 34-36 % of sulfamic acid, 24-26 % of oxalic acid, 4-6 % of biuret, 8-12 % of furazolidone, 8-12 % of 3-benzofuranone and 2.4-2.6 % of sodium nitrite. The low-carbon mixed organic acid is mainly used in a late stage of heavy oil throughput in Liaohe oilfield so as to improve single well production, especially to remove oil reservoir plug during each throughput, and is relatively substantial in improving steam throughput exploitation effects.