6 results about "Furazolidonum" patented technology

The methanol distillation device comprises a distillation cylinder, the upper end of the distillation cylinder is fixedly connected with a detachable cylinder cover, the middle of the upper end of the cylinder cover is fixedly connected with a motor, the output end of the motor is fixedly connected with a rotating shaft penetrating through the cylinder cover, the rotating shaft is fixedly connected with a plurality of stirring plates, and one side of the upper end of the cylinder cover is fixedly connected with a feeding port. A feeding valve is fixedly connected to the feeding hole; one side of the distillation cylinder is fixedly connected with a cooling box, the interior of the cooling box is fixedly connected with a condensation pipe, methanol is fully distilled, meanwhile, the device is convenient to move, the material receiving cylinder avoids the scattering phenomenon when furazolidone is discharged, the furazolidone is not prone to being contaminated by much dust in the air, and the device is convenient to use. And the cooling box and the condensation pipe are adopted, so that the methanol can be conveniently recycled, and the use is convenient.

The application discloses a chemical modified electrode for detecting furazolidone and an electrochemical detection method thereof, and relates to the technical field of electrochemical detection, and comprises the following steps: (1) preparation of longan carbon; (2) preparation of nitrogen-doped longan carbon material (NCs); (3) preparation of nitrogen-doped longan carbon-polydopamine material (NCs-PDA); (4) preparation of NCs-PDA / SPCE modified electrode; (5) electrochemical detection of FZD; and (6) characterization of NCs-PDA / SPCE. The chemical modified electrode for detecting furazolidone and the electrochemical detection method thereof use longan shells as a carbon source, chitosan and urea as nitrogen sources, and prepare a nitrogen-doped porous carbon material through a high-temperature carbonization method, combine polydopamine and a portable disposable screen-printed carbon electrode (SPCE), prepare an electrochemical modified electrode NCs-PDA / SPCE for detecting furazolidone, and establish an electrochemical rapid detection method for detecting furazolidone in animal-derived food based on the modified electrode.

The present application relates to the technical field of medicine preparation, more particularly, to a preparation and determination method of furazolidone single crystal with double bond cis-trans configuration. Furazolidone is added into a solvent, and is fully dissolved by vortexing, and is filtered to obtain a furazolidone saturated solution; the saturated solution is taken into a sample vial, and is sealed with a sealing film, a plurality of small holes are punched on the sealing film, and is left to stand, so that acetonitrile is slowly volatilized, and a crystal is grown to obtain a furazolidone single crystal with double bond cis-trans configuration. The solid state configuration of medicinal furazolidone is first confirmed: the furazolidone single crystal is successfully prepared by a solvent evaporation method, and high-precision single crystal X-ray diffraction technology (MoKα radiation, HyPix-Arc 150 detector) is combined with SHELXT program analysis, and it is first confirmed from the crystallographic level that the medicinal furazolidone is in a trans configuration in a solid state, which provides direct and irrefutable experimental evidence for the stereoscopic structure identification of the medicine.

The application discloses an electrochemical detection method of 3-amino-2-oxazolidinone (AOZ), and relates to the technical field of electrochemical detection, and comprises the following steps: (1) preparation of conjugated microporous polymer (CMP); (2) preparation of gold nanoparticles (AuNPs); (3) preparation of CMP / AuNPs / SPCE; (4) electrochemical detection of AOZ; and (5) characterization of CMP / AuNPs / SPCE. The electrochemical detection method of 3-amino-2-oxazolidinone is characterized in that gold nanoparticles with a large specific surface area and excellent conductivity and conjugated microporous polymer are drop-coated on the surface of a screen-printed carbon electrode (SPCE) to prepare an electrochemical modified electrode CMP / AuNPs / SPCE for measuring AOZ, and a differential pulse voltammetry method is used to establish an electrochemical detection method for measuring AOZ based on the modified electrode. The method is convenient for batch preparation and low in cost, only needs 30 muL of sample, and can be used for on-site rapid detection of AOZ, a furazolidone metabolite, in animal-derived food.

The present application relates to the technical field of medicine preparation, and more particularly to a preparation method of high-purity furanazole.S1 filters a solvent;S2 adds crude furanazole and the filtered solvent in S1 into a reaction tank, heats and stirs until completely dissolved, sequentially performs three times of cooling and stirring for crystallization, three times of centrifugation, collects filter cakes, dries, sieves and weighs to obtain finished furanazole.The finished product has high purity, the average value is greater than or equal to 99.9%, the purity is much higher than the purity of furanazole regulated by authoritative pharmacopoeias such as Chinese Pharmacopoeia and BP, the content of genotoxic impurity 5-nitro furfural is low, and the content is less than or equal to 10 ppm, which completely meets the limit requirement (less than or equal to 50 ppm) of ICH M7 (R1), greatly improves the purity standard of furanazole bulk drug, and is beneficial to drug safety.The present application has high yield, less waste, does not cause the burden of environmental pollution, is simple to operate, has few steps, has short production cycle, and is suitable for industrial large-scale production.