Natural drug extract

A technology of natural medicines and extracts, applied in the direction of drug combination, antineoplastic drugs, pharmaceutical formulations, etc.

Inactive Publication Date: 2013-10-09
石强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, Xeloda, etc., the incidence of chemotherapy-related diarrhea has increased year by year. Treatment can easily lead to dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc., which not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Effective treatment has become an important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that can relieve diarrhea and increase efficacy against cancer chemotherapy

Method used

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  • Natural drug extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0035] The first step: preparation of various extracts

[0036] (1) Preparation of concentrated extract of Andrographis lilac decoction

[0037] Take andrographis paniculata and cloves according to the compatibility ratio of 1:1, soak in distilled water, heat and decoct, filter with silk cloth, add distilled water to the dregs, soak, decoct, and filter in the same way, mix the two filtrates, heat and concentrate, and use an ultrafiltration membrane Filter, dry under reduced pressure, that is.

[0038] (2) Preparation of andrographolide

[0039] Take Andrographis paniculata powder, pre-treat with enzymatic hydrolysis, soak in ethanol, filter, recover ethanol, get extract, wash with petroleum ether, remove chlorophyll, extract the water layer with chloroform overnight, divide into water layer, chloroform layer and middle layer, The precipitate in the middle layer is recrystallized with ethanol to obtain that product.

[0040] (3) Preparation of clove ethanol extract

[0041]...

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Abstract

The invention relates to a natural drug extract. The natural drug extract consists of an extract prepared by decocting and concentrating common andrographis herb and clove in water, common andrographis herb lactone extract, clove ethanol extract and eugenol by a ratio of (4-6):(3-6):(2-4):(6-9). The composition has an extremely good treatment effect on diarrhea related with cancer chemotherapy and also has a synergism effect on cancer chemotherapy.

Description

technical field [0001] The present invention relates to a kind of natural medicine extract, more specifically relate to a kind of natural medicine extract that is composed of andrographis paniculata lilac decoction concentrated extract, andrographolide, clove ethanol extract and eugenol, the preparation of this natural medicine extract The method and the use of the natural medicine extract in preparing medicines for reducing cancer chemotherapy-related diarrhea and synergizing cancer treatment. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs, whether used alone or in combination, can cause toxic and side effects such as diarrhea in patients. Diarrhea after tumor chemotherapy is also called chemotherapy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61P35/00A61P1/12A61K31/085A61K31/365
Inventor 石强
Owner 石强
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