Citric acid calcium malate drug tablet

Abstract

The invention belongs to the technical field of a drug preparation, relates to a dosage form of an efficient calcium supplement agent, and particularly relates to a dosage form of a citric acid calcium malate drug tablet. According to the technical scheme, a citric acid calcium malate product which is more popular with people in need is provided in the way of improving he citric acid calcium malate product. The citric acid calcium malate drug tablet is characterized by only containing citric acid calcium malate drug instead of other ingredients; and concretely the citric acid calcium malate drug is made from powder in a direct tabletting manner. The citric acid calcium malate drug tablet has the advantages of high solubility, high absorption utilization, is safe and nontoxic, does not affect iron absorption of a human body, and does not destroy gastrointestinal acid-base balance.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical dosage forms, and relates to a dosage form of a high-efficiency calcium supplement, in particular to a pharmaceutical tablet dosage form of calcium citrate malate. Background technique [0002] Calcium citrate malate, also known as calcium citrate malate, calcium fruit acid, Calcium Citrate Malate, CCM, is a highly efficient calcium supplement. [0003] 1. The development and research status of calcium nutrition fortifiers [0004] Regarding the development and research status of calcium nutrition fortifiers (excerpted from Liu Hongling, 2007), there are more than 40 kinds of calcium nutrition fortifiers allowed to be used internationally. Nutrient enhancers include: active calcium, calcium carbonate, calcium aspartate, calcium acetate, calcium glycinate, natural bone meal, calcium citrate, calcium hydrogen phosphate, calcium lactate, calcium threonate, calcium gluconate 11 kinds, and Pra...

AI Technical Summary

Problems solved by technology

Organic calcium nutrition fortifiers have good solubility, little irritation to the gastrointestinal tract, and high hygiene and safety, but they generally have disadvantages such as low calcium content and varying degrees of toxic and side effects (Yang Zhen et al., 2006)

For example, the lactic acid root contained in calcium lactate is easy to bring fatigue to the human body (Zhou Jun, 2002), the calcium content of calcium gluconate is low, the intestinal calcium absorption rate is not high, and it is not suitable for diabetic patients (Lv Weiqing, 2000); The solubility of calcium citrate is very low, so it is not suitable for liquid food or solid food that needs to be prepared, and it has been found through research that calcium citrate will promote the absorption of metal ions and aluminum ions by the human body, which is not conducive to health (Lin Xufang, 2005) ;Calcium acetate is a better inhibitor of phosphorus in hyperphosphatemia, but it is rarely used as a calcium supplement, which may be related to its tendency to cause hypercalcemia and calcification of some soft tissues, so it has not been certified by the US FDA. Studies have shown that calcium acetate can seriously inhibit the absorption of trace element zinc in the small intestine (Hwang S J. Lai Y H, 1992), so it cannot be taken for a long time

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