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Application of Nardoaristolones A in preparing medicines for treating rheumatoid arthritis

An arthritis and rheumatoid technology, applied in the field of compounds, can solve problems such as ulcers, poor action selectivity, and damage to the gastrointestinal mucosa, and achieve the effect of strong inhibitory activity and outstanding substantive characteristics

Active Publication Date: 2013-11-20
SHANGHAI STEPPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection, etc.

Method used

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  • Application of Nardoaristolones A in preparing medicines for treating rheumatoid arthritis
  • Application of Nardoaristolones A in preparing medicines for treating rheumatoid arthritis
  • Application of Nardoaristolones A in preparing medicines for treating rheumatoid arthritis

Examples

Experimental program
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Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Nardoaristolones A tablet involved in the present invention:

[0013] Take 5 grams of compound Nardoaristolones A, add 195 grams of dextrin, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Nardoaristolones A capsules involved in the present invention:

[0015] Get 5 grams of compound Nardoaristolones A, add 195 grams of starch, mix well, pack into capsules and make 1000 capsules.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1, the influence of Nardoaristolones A of the present invention on rat adjuvant arthritis

[0018] Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the base of the tail. The difference of , represents the degree of swelling. On the 16th day after the injection of the adjuvant, the swelling of the left hind foot of the rats was obvious. The rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally administered Nardoaristolones A5.0, 10.0, and 20.0 mg / kg of the present invention, and the positive control group was orally administered Diclofenac 10mg / kg, the control group was given the same volume of distilled water, once...

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PUM

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Abstract

The invention relates to Nardoaristolones A for treating immune inflammation and the Nardoaristolones can be used for preparing medicines for treating rheumatoid arthritis. Terfenadine and diclofenac sodium are taken as control, and the curative effect of Nardoaristolones A is exact. The use of Nardoaristolones A for preparing medicines for treating rheumatoid arthritis provided by the invention is disclosed for the first time. As the framework type belongs to a brand-new framework type, Nardoaristolones A has remarkable substantive characteristics and obviously has remarkable progress for preventing and treating rheumatoid arthritis.

Description

technical field [0001] The present invention relates to the new use of compound Nardoaristolones A, in particular to the application of Nardoaristolones A in the preparation of medicines for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a clinical common disease and frequently-occurring disease. Rheumatoid arthritis belongs to autoimmune disease and belongs to the category of immune inflammation. At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection. Therefore, compounds with well-defined components, controllable quality, safety and high efficiency have potential value in the development of drugs for rheumatoid arthritis. [0003] The compound Nardoaristolones A involved in the present invention is published in 2013 (Ming-Li Liu, Ying...

Claims

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Application Information

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IPC IPC(8): A61K31/343A61P19/02A61P29/00
Inventor 张延
Owner SHANGHAI STEPPHARM CO LTD
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