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Applications of compound in preparation anti human body fungus drugs

A technology against human fungi and compounds, applied in the direction of antifungal agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of strong accumulation of toxicity, irritation, dizziness, allergies, etc., and achieve the effect of highlighting substantive characteristics

Active Publication Date: 2013-11-20
深圳市茵诺圣生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pathogenic fungi seriously threaten human health and life. Antifungal drugs have been widely used as routine medications. Currently, clinically used antibacterial agents (such as ketoconazole, amikacin, gentamycin, vigorconazole, Itraconazole, terbinafine, amphotericin, fluconazole, etc.) have good curative effect on skin and superficial infection, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, digestive tract Stimulation, dizziness, allergies, etc., so looking for new antifungal drugs with a unique mechanism of action has become one of the hot spots in drug research and development today

Method used

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  • Applications of compound in preparation anti human body fungus drugs
  • Applications of compound in preparation anti human body fungus drugs
  • Applications of compound in preparation anti human body fungus drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of compound Kadcoccitones A tablet involved in the present invention:

[0013] Take 5 grams of compound Kadcoccitones A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0014] Embodiment 2: the preparation of compound Kadcoccitones A capsules involved in the present invention:

[0015] Take 5 grams of compound Kadcoccitones A, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0017] Experimental example 1: Kadcoccitones A anti-human fungal activity

[0018] The anti-fungal activity experiment against human body adopts the method of concentration dilution, and each determination is repeated three times. The test pathogens include Trichomonas rubrum, Microsporum lanoides and Trichomonas clumps, and the concentration of bacteria solution is 105 / mL. The initial concentration of Kadcoccitones A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the equal volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the human fungal culture temperature 28°C respectively, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Kadcoccitones A against human fungi are shown in Table 1.

[0019] Table 1 Kadcoccitones A anti-h...

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Abstract

The invention relates to applications of Kadcoccitones A in preparation anti human body fungus drugs, and belongs to the field of medicine. Kadcoccitones A has strong functions of inhibiting trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, so that Kadcoccitones A can be taken as a compound with the function of anti human body fungi, and is advantageously used for corresponding drugs.

Description

technical field [0001] The present invention relates to the new use of compound Kadcoccitones A, in particular to the application of Kadcoccitones A in the preparation of antifungal drugs for human body. Background technique [0002] Pathogenic fungi seriously threaten human health and life. Antifungal drugs have been widely used as routine medications. Currently, clinically used antibacterial agents (such as ketoconazole, amikacin, gentamycin, vigorconazole, Itraconazole, terbinafine, amphotericin, fluconazole, etc.) have good curative effect on skin and superficial infection, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, digestive tract Stimulation, dizziness, allergies, etc., so looking for new antifungal drugs with unique mechanism of action has become one of the hot spots in drug research and development today. [0003] The compound Kadcoccitones A involved in the present invention is a 2012 publication (Cheng-Qin...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P31/10
Inventor 章苏凤
Owner 深圳市茵诺圣生物科技有限公司
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