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Centella asiatica (l.) urban effective fraction and application thereof

A technology of effective parts, Centella asiatica, applied in the field of effective parts of Centella asiatica and its extraction, can solve problems such as drugs that have not yet found special effects

Inactive Publication Date: 2013-11-20
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

No effective drug has been found clinically so far

Method used

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  • Centella asiatica (l.) urban effective fraction and application thereof
  • Centella asiatica (l.) urban effective fraction and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Weigh 25.0kg of dried Centella asiatica coarse powder, soak and extract three times with 95%, 70%, and 50% ethanol successively, soak for 4 to 5 days each time, combine the extracts, reclaim ethanol under reduced pressure, and obtain the total ethanol extract of about 9kg. Add water to dissolve into a suspension, then extract with ethyl acetate, and recover the solvent under reduced pressure to obtain 186.0 g of ethyl acetate.

[0036] The centella asiatica ethyl acetate part is added with suitable pharmaceutical excipients to make corresponding pharmaceutical dosage forms, such as capsules, tablets, granules, powders, oral liquids or pills, and the medicine made by using the product of the present invention is obtained.

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Abstract

The present invention discloses an extracted centella asiatica (l.) urban effective fraction, and further discloses a preparation method for the effective fraction, wherein the effective fraction is prepared by performing a system separation method on centella asiatica (l.) urban. In addition, the present invention discloses an application of the effective fraction in anti-Alzheimer's disease drug preparation.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to the effective part of Centella asiatica and its extraction method and application. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a frequently occurring common disease, and its incidence increases with age. Modern medicine studies on the pathogenesis of senile dementia believe that senile dementia is a primary brain neurodegenerative disease caused by multiple factors, which is characterized by a large loss of central cholinergic neurons, accompanied by neuritis The formation of plaques and neurofibrillary tangles, and the deposition of amyloid β-protein (β-AP) containing β-sheet structures affect the release of transmitters, eventually leading to memory loss and behavioral abnormalities. Clinically, no effective drug has been found so far. Therefore, it is of great significance to deeply explore the pathogenesis of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P25/28
Inventor 钟振国卢汝梅杜正彩
Owner GUANGXI UNIV OF CHINESE MEDICINE
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