BED (biological effective dose)-based prediction method for complications caused by tumor radiotherapy

Abstract

The invention provides a BED (biological effective dose)-based prediction method for complications caused by tumor radiotherapy. The method comprises the following steps of improving the conventional NTCP (normal tissue complication probability) model by using the concept of a BED, and performing fractionated dose correction on the model by introducing an alpha / beta factor; reviewing and analyzing dose-volume parameters of irradiation to a certain organ after a group of patients receive radiotherapy and follow-up results, which are obtained by clinical observation after the radiotherapy, about the occurrence of the complications on the organ, and performing synchronous fitting on model parameters and the alpha / beta factor by utilizing the improved NTCP model; and substituting the NTCP model parameters and the alpha / beta factor, which are obtained by fitting, and the dose-volume information of the organs of a group of patients to receive the radiotherapy into the improved NTCP model, and calculating a probability value of occurrence of the complications on the organs of the patients in the group. Therefore, the probability of occurrence of the complications on the organ after the tumor patients in the group receive different fractionated doses of irradiation is predicted.

Description

technical field [0001] The invention relates to a technique for predicting clinical complications of radiotherapy, in particular to a method for predicting complications of tumor radiotherapy based on biological effect dose. Background technique [0002] The purpose of tumor radiation therapy is to improve the local control rate of tumors by increasing the dose of the target area (tumor) and reducing the radiation damage to normal tissues (organs at risk) around the target area, thereby further improving the survival rate of cancer patients and improving the quality of life of patients. However, the location of the tumor is usually located in the patient's body, and the radiation must pass through some normal tissues while penetrating the human body, and the side scattering of X-rays also increases the radiation dose to normal tissues around the target area. Radiotherapy techniques cannot avoid mis-irradiation of normal tissues around the target area. Organs in the human bo...

AI Technical Summary

Problems solved by technology

Since both patients received the same total prescribed dose (70Gy), it is not possible to see a difference in the possible complications of bladder irradiation between the two patients

However, clinical experience and statistical results show that patients who receive high-dose fractionation have a higher probability of complications than patients who receive conventional fractionation, and the difference is significant

In this case, since the traditional NTCP model is completely based on the cumulative DVH diagram of the total amount of radiation received by a patient’s organ, and does not consider the impact of different fractional dose regimens on complications, the probability of complications in the above two patients is will give the same predicted result, which does not match the actual

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