Accurate droplet generation method based on electrowetting-on-dielectric digital microfluidic chip

Abstract

The invention belongs to the technical field of digital microfluidics and in particular provides an accurate droplet generation technology based on an electrowetting-on-dielectric digital microfluidic chip. The technology is characterized by being realized by virtue of design of driving electrodes of the digital microfluidic chip and driving signal operation, wherein in the droplet fission and generation position, special micro-electrodes are used for forming an electrode group to replace traditional single electrodes; when used integrally, the electrode group is identical with conventional electrodes and can achieve droplet pull-out while the micro-electrodes in the electrode group can achieve stable and accurate droplet fission through independent driving signal operation, thus achieving accurate droplet generation. The technology is simple in achievement structure, is compatible with the chips in the current field, is convenient to control, can be used for greatly improving the droplet generation accuracy in the field of digital microfluidics and has great significance for commercial application.

Description

technical field [0001] The invention belongs to the technical field of digital microfluidics, and in particular relates to a method for generating precise droplets based on a dielectric electrowetting digital microfluidic chip. Background technique [0002] The digital microfluidic technology based on the dielectric electrowetting effect refers to the microfluidic technology that changes the wettability of the droplet on the surface of the medium by applying a voltage on the dielectric structure, thereby changing the contact angle between the droplet and the interface to further manipulate the discrete droplet. , it has many advantages such as simple driving method, strong driving force, convenient operation, and high degree of automation. It is the mainstream technology in the field of digital microfluidics and has very good development prospects in the field of LOC. A digital microfluidic chip based on dielectric electrowetting usually includes four parts, an electrode lay...

AI Technical Summary

Problems solved by technology

Therefore, in the field of traditional dielectric electrowetting digital microfluidics, the inaccuracy of droplet generation is an important bottleneck for its commercial application, although there are reports that continuous microflow precision control pumps can be added to digital microfluidic chips to provide precise droplets. , but this obviously does not meet the integration and portability of lab-on-a-chip

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