Method for preparing non-human animal model with opportunistic infections and chronic wasting diseases and medicament screened by using same
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A non-human animal, consumable technology, applied in the direction of anti-infective drugs, allergic diseases, metabolic diseases, etc., can solve problems such as adverse reactions, limited clinical efficacy, tissue and organ damage, achieve no toxic side effects, reduce mortality, The effect of prolonging life
Inactive Publication Date: 2013-12-11
GUILIN MEDICAL UNIVERSITY
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(2) Congenital immunodeficiency
(3) Secondary immunodeficiency
In addition, the cause and formation mechanism of acquired immunodeficiency syndrome caused by non-HIV virus factors are still unclear, and its treatment is also an urgent problem to be solved
(5) Long-term application of certain antibiotics can inhibit the normal flora, which is conducive to the growth of certain conditional pathogens such as fungi, leading to opportunistic infections
Commonly used anti-infective drugs, such as antibacterial drugs, antifungal drugs, antiviral drugs, etc., but the application of anti-infective drugs will bring different degrees and types of adverse reactions, such as drug resistance, the double effect of long-term application of broad-spectrum antibacterial drugs "Immune Reconstitution Inflammatory Syndrome (IRIS)" after infection and AIDS antiretroviral therapy (ART) -- abnormal manifestations of worsening clinical symptoms and damage to important tissues and organs during the process of rebuilding the body's immune function
(2) Try to improve the immune function of the human body, such as strengthening nutrition, transfusing fresh blood or white blood cells, injecting γ-globulin, thymosin, specific immune ribonucleic acid, etc., but the clinical curative effect is limited and brings certain adverse reactions
The study of animal models of opportunistic infections and chronic wasting diseases with the characteristics of traditional Chinese medicine syndromes is blank, and the screening of opportunistic infections and chronic wasting diseases Therapeutic drugs and scientific and objective evaluation of curative effect have brought obvious obstacles
Method used
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[0064] (2) Add 3220g of water, boil and extract on low heat for 6 hours;
[0065] (3) Remove residue by filtration to obtain 450ml of water extract. That is, each milliliter contains 1 gram of crude drug.
[0066] The obtained water extract is the traditional Chinese medicine compound for treating opportunistic infection and chronic wasting disease.
[0067] Modeling and Drug Therapy
[0068] Seventy-two Kunming male mice, weighing 16.9±2 g, aged 1 month, were provided by the Animal Experiment Center of Guilin Medical College, license number: GLMC20130308HL.
[0069] The 1-month-old clean-grade male mice were randomly divided into 2 groups: ① Normal control group (CTRL, 24 mice): 9:00-9:30, 12:30-13:00, 17:00-17 :30 Swimming in three time periods, giving 3ml of distilled water at 28°C after each swimming, for ...
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Abstract
The invention discloses a method for establishing an animal model with opportunistic infections and chronic wasting diseases, and a traditional Chinese medicinal preparation for treating opportunistic infections and chronic wasting diseases. The traditional Chinese medicinal preparation is prepared by the following components in parts by weight: 100-180 parts of monkhood, 100-180 parts of dry ginger, and 100-160 parts of liquorice. The method has the positive effects that the method for establishing the animal model with opportunistic infections and chronic wasting diseases is found, and the model has high controllability, reliability and repeatability, and is convenient and economical to use; the model syndrome accords with the attack process of opportunistic infections and chronic wasting diseases; the model establishing factor accords with the theory of the Internal Canon of Medicine, and does not relates to causal organisms, so that the testing risks can be reduced, and the organism safety can be guaranteed; the traditional Chinese medicinal preparation obtained by screening has the characteristics of high efficiency, no toxicity, wide medicine sources and the like, is convenient to use and economical, can be used for prolonging the life of patients with opportunistic infections and chronic wasting diseases, improving the living quality of the patients and improving lesion of each tissue, and does not have toxic or side effect when a large dosage is used.
Description
technical field [0001] The invention relates to a non-human animal model, in particular to a method for preparing a non-human animal model of opportunistic infection and chronic wasting disease. The invention also relates to a screening method using the model, and the screened drug for treating opportunistic infection and chronic wasting disease. Background technique [0002] Opportunistic infection refers to some pathogenic pathogens with weak pathogenicity, which cannot cause disease when the human immune function is normal, but when the human immune function is weakened, they take advantage of the weak point and invade the human body, causing various diseases. Normal flora can also cause infection under certain conditions such as low immune function of the body, changes in the site of residence, or imbalance of flora. It can be seen in the following situations: (1) The surface barrier function of the skin and mucous membrane is damaged, such as injury, burn, intubation, ...
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