(R)-1,2-propanediol for use as solvent in therapeutic cooling agent compositions
A technology of composition and cooling agent, applied in the field of topical drug therapy, cosmetics, and toiletries, which can solve the problems of individual sensitivity changes, interference detection of cooling sensation, etc.
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[0039] (R)-1,2-Propanediol
[0040] If the topical coolant is delivered in a medium that is liquid or partially liquid, it is desirable to have a solvent for the coolant that will not interfere with biological activity (eg, its cooling activity).
[0041] The inventors have found that the test substance can be tested by dissolving it in the test solvent and using a cotton-tipped applicator (for example, ) to test the cooling and sensory properties of the substances to be tested in various solvents by applying 0.10 to 0.25 mL of the solution alone on the skin surface. Reliable locations for topical application are the skin above the upper lip (above the vermilion of the lips), on the philtrum, transverse to the philtrum up to the nasolabial fold, and under the nostrils (subnasal septal point). This part of the face is known to be densely innervated by cold receptors, second only to the eyeballs and the anogenital (anogenital) surface. Tingling, cooling and cooling sensatio...
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Abstract
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