(R)-1,2-propanediol for use as solvent in therapeutic cooling agent compositions

A technology of composition and cooling agent, applied in the field of topical drug therapy, cosmetics, and toiletries, which can solve the problems of individual sensitivity changes, interference detection of cooling sensation, etc.

Inactive Publication Date: 2013-12-18
魏德烽
View PDF9 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In these studies on menthol-like coolants, ethanol was often used as a solvent to aid in placement of the coolant on the filter paper and could lead to variations in individual sensitivity (since, ethanol, as the primary solvent, is known to interfere with the detection of cooling sense)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • (R)-1,2-propanediol for use as solvent in therapeutic cooling agent compositions
  • (R)-1,2-propanediol for use as solvent in therapeutic cooling agent compositions
  • (R)-1,2-propanediol for use as solvent in therapeutic cooling agent compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0039] (R)-1,2-Propanediol

[0040] If the topical coolant is delivered in a medium that is liquid or partially liquid, it is desirable to have a solvent for the coolant that will not interfere with biological activity (eg, its cooling activity).

[0041] The inventors have found that the test substance can be tested by dissolving it in the test solvent and using a cotton-tipped applicator (for example, ) to test the cooling and sensory properties of the substances to be tested in various solvents by applying 0.10 to 0.25 mL of the solution alone on the skin surface. Reliable locations for topical application are the skin above the upper lip (above the vermilion of the lips), on the philtrum, transverse to the philtrum up to the nasolabial fold, and under the nostrils (subnasal septal point). This part of the face is known to be densely innervated by cold receptors, second only to the eyeballs and the anogenital (anogenital) surface. Tingling, cooling and cooling sensatio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates generally to the field of topical medical therapy, cosmetics, and toiletries. More specifically, the invention relates to the use of a solvent comprising (R)-1,2-propanediol for cooling agents, for example, (R)-2-[((1fl,2S,5R)-2-isopropyl- 5-methyl-cyclohexanecarbonyl)-arnino]-propionic acid n-propyl ester (CPS-410). The invention also relates to cooling agent compositions comprising a cooling agent and, 2-propanediol, and methods for their preparation. The invention also relates to the use of such cooling agent compositions in therapy, for example, in the treatment of sensory discomfort, especially sensory discomfort of the skin (e.g., itch). The invention also relates to the use of such cooling agent compositions in cosmetics (e.g., eye make-up products) and toiletries (e.g., after-shave lotion).

Description

[0001] related application [0002] This application is related to US Patent Application No. US 12 / 930,794, filed January 18, 2011, the entire contents of which are hereby incorporated by reference. technical field [0003] The present invention relates generally to the fields of topical medical treatments, cosmetics, and toiletries. More specifically, the present invention relates to the use of solvents comprising (R)-1,2-propanediol, for example, (R)-2-[((1R,2S,5R)-2-isopropyl- 5-Methyl-cyclohexanecarbonyl)-amino]-propionic acid n-propyl ester (CPS-410). The present invention also relates to coolant compositions comprising coolant and (R)-1,2-propanediol, and methods for their preparation. The present invention also relates to the use of a coolant composition as described above in therapy, eg in the treatment of sensory discomfort, especially of the skin (eg pruritus). The present invention also relates to the use of the above-mentioned coolant composition in cosmetics (e...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/10A61P11/00A61P17/04A61K31/223
CPCA61K8/345A61K9/0014A61K9/08A61K31/16A61K31/223A61K31/66A61P1/02A61P9/14A61P11/00A61P11/02A61P11/06A61P15/00A61P17/00A61P17/02A61P17/04A61P17/06A61P17/08A61P27/16A61P29/00A61P31/04A61P31/22A61P37/08A61Q19/002
Inventor 魏德烽
Owner 魏德烽
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap