Ibuprofen suspension and preparation method thereof

A kind of suspension and suspension technology, applied in the field of medicine, can solve the problems of easy recurrence and repeated respiratory tract infection in children, and achieve the effect of good stability, not easy to float, and simple and feasible preparation process

Active Publication Date: 2013-12-25
仁和堂药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the treatment of recurrent respiratory tract infection in children, overcome the obvious shortc

Method used

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  • Ibuprofen suspension and preparation method thereof
  • Ibuprofen suspension and preparation method thereof
  • Ibuprofen suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] Example 1

[0028] Prepare 1000ml ibuprofen suspension:

[0029] Weigh 20g ibuprofen, 7.5g microcrystalline cellulose, 1.5g gum arabic, 500g sucrose, 100g glycerin, 1g sodium carboxymethyl cellulose, 1.6g lemon flavor, 803g Tween, 2.5g sodium benzoate, and ethylenediamine tetra Disodium acetate 0.5g, carmine 0.005g, sorbitol liquid 100g, citric acid 1.425g

[0030] 1 Preparation of ibuprofen slurry

[0031] Take the sorbitol liquid, glycerin, and sodium carboxymethyl cellulose, stir for 10 minutes, and heat to 70°C until the gum is completely hydrated. Then cool the hydrate to 45°C and add Tween 80. When the mixture is cooled to 30°C, continue to mix for about 15 minutes, then add ibuprofen, and continue to mix for 15 minutes;

[0032] 2 Preparation of suspension

[0033] First prepare a 1% gum arabic aqueous solution. Take 150 mL of water, slowly add 1.5 g of gum arabic, mix for about 25 minutes to make a 1% gum arabic aqueous solution, and add microcrystalline cellulose.

[00...

Example Embodiment

[0035] Example 2

[0036] An ibuprofen suspension, which is characterized in that a main drug is added to pharmaceutical excipients, suspended, configured into a solution, sterilized and subpackaged, and the main drug is prepared from the following raw materials: ibuprofen 7g, Bupleurum 30g, Coptis 30g, Dandelion 20g, Two-faced needle 15g, Pinellia 10g, Angelica dahurica 10g, Ginseng 5g, Turmeric 5g, Pomegranate peel 3g, Licorice 3g.

[0037] The preparation method is:

[0038] 1 Preparation of concentrated solution:

[0039] Take 30g of Bupleurum, 30g of Coptis, 20g of dandelion, 15g of liangmianzhen, 10g of pinellia, 10g of Angelica dahurica, 5g of ginseng, 5g of turmeric, 3g of pomegranate peel, 3g of licorice, add water to decoc three times, add 5 times the amount of water each time, soak , Decocting, and filtering; waste medicine residue, combine the filtrate, and concentrate by evaporation under reduced pressure to a concentrated solution of 1.10 to 1.15 when the relative densi...

Example Embodiment

[0046] Example 3

[0047] 1. Toxicity test:

[0048] In this experiment, healthy SD rats were used for oral administration. The dose gradients prepared in Example 1 and Example 2 were both 0.1ml / kg and 0.5ml / kg. The drug was administered continuously for 30 days. Animal growth status, active diet, hematology, blood biochemistry, organ tissue structure, and urine routine within 1 week after the drug have no significant impact, indicating that clinical medication is safe and reliable.

[0049] 2. Analgesia experiment:

[0050] The effect on the writhing response of BALB / c mice caused by acetic acid: 60 BALB / c mice, half male and half, with an average weight of 20.3g, were randomly divided into 3 groups, namely the physiological saline group, the drug group of Example 1, and Example 2 Drug group; once a day, the dose is 0.25ml / kg (the experimental group is given the drug, and the control group is given the same weight of normal saline), continuous intragastric administration for 3 days,...

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Abstract

The invention relates to an ibuprofen suspension and a preparation method thereof. The ibuprofen suspension is a Chinese and western compound preparation, a primary medicine of the ibuprofen suspension comprises ibuprofen, the primary medicine is added to auxiliary medicines of the ibuprofen suspension to make the primary medicine suspend in order to prepare a suspension, and the suspension is disinfected and packaged to obtain the ibuprofen suspension. The ibuprofen suspension can simultaneously treat the principle and subordinate symptoms of infantile recurrent respiratory tract infection and infantile fevers, and has the advantages of non-toxicity and innocuousness to human bodies, no side effects, low price, simple preparation and wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an ibuprofen suspension and a preparation method thereof. Background technique [0002] Recurrent respiratory tract infection in children is a common and frequently-occurring disease in clinical practice. Modern medicine believes that the exact pathogenesis is still not completely clear, and it is the result of the combined effect of various factors, and low immune function is considered to be one of the important reasons for the disease. In the prior art, the research on the treatment of children with exogenous fever is roughly (1) physical cooling, such as warm water or alcohol scrub bath, ice pack cooling, saline enema, etc.; (2) drug cooling, such as oral antipyretics, analgin Intranasal or intramuscular injection, intravenous infusion of dexamethasone and other drugs, while taking antibiotics to treat infection; (3) Chinese medicine therapy: such as oral Chines...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/192A61K36/9066A61P11/00A61P31/12A61P29/00A61P37/04
Inventor 林凡友林凡儒
Owner 仁和堂药业有限公司
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