Cefalexin capsules and preparation method thereof

A technology of cephalexin capsules and ampicillin capsules, which is applied in the field of medicine, can solve the problems of easy hydrolysis of cephalexin, and achieve the effects of good stability, rapid dissolution and simple preparation process

Inactive Publication Date: 2013-12-25
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the deficiencies in the prior art, the inventor intend

Method used

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  • Cefalexin capsules and preparation method thereof
  • Cefalexin capsules and preparation method thereof
  • Cefalexin capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 cephalexin capsules

[0020]

[0021]

[0022] Preparation Process

[0023] Cefalexin passed through a 100-mesh sieve, added to the prescribed amount of Span 80, stirred evenly, added calcium hydrogen phosphate passed through an 80-mesh sieve for adsorption, finally mixed with micronized silica gel, and filled into capsules.

Embodiment 2

[0024] The preparation of embodiment 2 cephalexin capsules

[0025]

[0026] Preparation Process

[0027] Cefalexin is passed through a 120 mesh sieve, added to the prescription amount of Span 85, stirred evenly, added calcium hydrogen phosphate and calcium carbonate passed through an 80 mesh sieve for adsorption, finally mixed with talcum powder, and filled into capsules.

Embodiment 3

[0028] The preparation of embodiment 3 cephalexin capsules

[0029]

[0030] Preparation Process

[0031] Cephalexin passed through a 100-mesh sieve, added to the prescribed amount of Span 80, stirred evenly, added calcium sulfate passed through an 80-mesh sieve for adsorption, and finally mixed with micronized silica gel, and filled into capsules.

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PUM

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Abstract

The invention discloses cefalexin capsules and a preparation method thereof. The capsules consist of filler and capsule shells, wherein the filler is prepared by uniformly mixing medicine-containing fine powder and a lubricant, and the medicine-containing fine powder is prepared from cefalexin, span and neutral inorganic salt. The preparation method comprises the following steps: uniformly mixing the cefalexin in the span; adding the inorganic salt, adsorbing to obtain the medicine-containing fine powder; and mixing the medicine-containing fine powder and the lubricant, and filling into capsule shells. The capsules have the advantages of good stability and quick dissolution, is simple in preparation process, and is suitable for scale production requirement.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a cephalexin capsule and a preparation method thereof. Background technique [0002] Cephradine (Cephradine, Velosef), aliased as cephalosporin IV, cephalosporin IV, etc., is the first generation of semi-synthetic cephalosporins. This product is acid-resistant and can be taken orally, with good absorption and high blood concentration. It is characterized by resistance to β-lactamase. This product has a good antibacterial effect on Neisseria, but Haemophilus influenzae is less sensitive to this product; The product has a certain antibacterial effect on some Escherichia coli, Proteus mirabilis, Salmonella and Shigella. The remaining Enterobacteriaceae, Acinetobacter, Pseudomonas aeruginosa, and Bacteroides fragilis all showed resistance to this product. Fusobacterium and Veillonella are generally sensitive to this product, and anaerobic Gram-positive cocci are modera...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/545A61K47/02A61K47/22A61P31/04
Inventor 不公告发明人
Owner NANJING ZHENGLIANG MEDICAL TECH
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