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Calcium zinc gluconate granule and its preparation method

A technology of calcium zinc gluconate and calcium gluconate, applied in the field of calcium zinc gluconate granules and preparation methods thereof, can solve problems such as poor stability of calcium zinc gluconate oral solution, and ensure the safety and compatibility of medication. The effect of good sex and improving the safety of medication

Active Publication Date: 2015-09-16
GUIZHOU LIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the lack of quality control of lysine hydrochloride, there is a problem of poor stability of calcium zinc gluconate oral solution

Method used

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  • Calcium zinc gluconate granule and its preparation method
  • Calcium zinc gluconate granule and its preparation method
  • Calcium zinc gluconate granule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A calcium zinc gluconate granule, the formula in parts by weight is as follows:

[0022]

[0023] Preparation method: crush calcium gluconate, zinc gluconate, and lysine hydrochloride through a 80-mesh sieve, mix evenly with the sweetener, add a binder dissolved in purified water, mix and granulate, dry at 60°C and sieve through a 24-mesh sieve Whole grains, add solid powder essence and mix evenly, then pack in composite film bags.

Embodiment 2

[0025] A calcium zinc gluconate granule, the formula in parts by weight is as follows:

[0026]

[0027] Preparation method: Calcium gluconate, zinc gluconate, and lysine hydrochloride are crushed through an 80-mesh sieve, mixed evenly with sweeteners and excipients, added with a binder dissolved in purified water, mixed and granulated, and dried at 60°C Finally, sieve with 24 meshes for granulation, add solid powder essence and mix evenly, then pack in composite film bags.

Embodiment 3

[0029] A calcium-zinc gluconate granule, the formula in parts by weight is as follows, and the preparation method is the same as in Example 1.

[0030]

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PUM

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Abstract

The invention discloses calcium zinc gluconate granules and a preparation method thereof. The calcium zinc gluconate granules contain calcium gluconate, zinc gluconate, lysine hydrochloride, an excipient, a sweetening agent, an adhesive and essence. The excipient can be selected from sucrose, lactose, maltose and maltodextrin; an acidulant cannot be selected; the sweetening agent can be selected from steviosin and sucralose; the adhesive is preferably selected from the sucrose, the maltose and the maltodextrin. Compared with oral solution, the granules disclosed by the invention have more stable quality, good taste, convenience in medicament taking, and high compliance.

Description

technical field [0001] The invention relates to a calcium zinc gluconate granule and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] When children lack calcium, it is difficult to fall asleep, difficult to enter deep sleep, crying after falling asleep, easy to wake up, sweating after falling asleep; paroxysmal abdominal pain, diarrhea, cramps, "X'-shaped legs, "O"-shaped legs, chicken breasts, Gray nails or white marks; anorexia, partial eclipse; daytime irritability, restlessness; late mental development, late speech; Sparse hair; poor health, easy to catch a cold, etc. [0003] Zinc is a component or coenzyme of six major enzymes and 200 metalloenzymes in the human body, and plays a broad role in systemic metabolism. When zinc is deficient, the prominent manifestations are loss of appetite, growth retardation, pica and dermatitis, which mostly occur in children less than six years old. [0004] Lysine hydrochlori...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/198A61K9/16A61K47/26A61P3/02A61K31/191
Inventor 王超志涂涛
Owner GUIZHOU LIANSHENG PHARMA
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