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Application of Lycojaponicumin B in human fungus resisting medicine

A technology against human fungi and drugs, applied in the direction of antifungal agents, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of digestive tract irritation, strong accumulation of toxicity, etc. Active effect

Active Publication Date: 2013-12-25
王晓燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Lycojaponicumin B in human fungus resisting medicine
  • Application of Lycojaponicumin B in human fungus resisting medicine
  • Application of Lycojaponicumin B in human fungus resisting medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound Lycojaponicumin B tablet involved in the present invention:

[0013] Take 20 grams of compound Lycojaponicumin B, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet machine.

Embodiment 2

[0014] Embodiment 2: the preparation of the compound Lycojaponicumin B capsules involved in the present invention:

[0015] Get 20 grams of compound Lycojaponicumin B, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental example: Lycojaponicumin B anti-human fungal activity

[0018] Anti-human fungus activity experiment is the method of concentration dilution, each determination is repeated three times, the test pathogens are Trichophyton rubrum, Microsporum lanoides and Trichophyton aureus, and the concentration of bacteria solution is 10 5 individual / mL. The initial concentration of Lycojaponicumin B is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, the equal volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the human fungal culture temperature 28 ℃ respectively, observe after 24 hours of incubation time, if no colony is found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Lycojaponicumin B against human fungi are shown in Table 1.

[0019] Table 1 Lycojaponicumin B anti-human fungal MIC...

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Abstract

The invention relates to an application of Lycojaponicumin B in preparation of a human fungus resisting medicine, belonging to the field of medicines. The Lycojaponicumin B has strong effects of inhibiting trichophyton rubrum, Microsporum lanosum or Trichophyton tonsurans, therefore, the Lycojaponicumin B can be used as a compound with a human fungus resisting function, and is expected to be applied in the preparation of the related medicines. The application of the Lycojaponicumin B in preparation of the human fungus resisting medicine, disclosed by the invention, is disclosed for the first time. The skeleton type of the Lycojaponicumin B belongs to a brand-new skeleton type, and the human fungus inhibiting activity of the Lycojaponicumin B is unexpectedly strong, so that no possibility for providing any inspiration by other compounds exists. The Lycojaponicumin B has outstanding substantial characteristics, meanwhile, has a significant progress in prevention and treatment of human fungal infection.

Description

technical field [0001] The present invention relates to the application of Lycojaponicumin B, in particular to the application of Lycojaponicumin B in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound Lycojapon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/424A61P31/10
Inventor 江春平吴俊艺
Owner 王晓燕
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