Use of rhizoma smilacis glabrae extract in preparation of lipid-lowering and fat-reducing medicines and health-care foods

A technology of Smilax tuckahoe extract and lipid-lowering and weight-loss technology, which is applied in the field of medicine, can solve the problems that there are no research reports on fat-lowering and weight-loss of Smilax tuckahoe extract, and achieve good weight-loss effect and strong fat-lowering and weight-loss effect

Active Publication Date: 2015-03-11
JIANGI WENIR NUTRITION HIGH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there is no research report on fat-lowering and weight-loss aspects of Smilax tuckahoe extract

Method used

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  • Use of rhizoma smilacis glabrae extract in preparation of lipid-lowering and fat-reducing medicines and health-care foods
  • Use of rhizoma smilacis glabrae extract in preparation of lipid-lowering and fat-reducing medicines and health-care foods
  • Use of rhizoma smilacis glabrae extract in preparation of lipid-lowering and fat-reducing medicines and health-care foods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The Smilax Smilax Lipid-Reducing Slimming Capsules are prepared through the following steps:

[0046] (1) Smilax smilax extract: Smilax smilax was crushed through a 40-mesh sieve, ultrasonically extracted with 10 times the volume of 60% ethanol, 60 o C recovers the ethanol in the extraction solvent under reduced pressure, and obtains the supernatant after centrifugation. Add 40-60 mesh β-cyclodextrin-starch resin with the same weight as Smilax smilax to the supernatant, oscillate and absorb for 30 minutes, then filter, and the resin is eluted twice with 60% ethanol, collect the eluate, and recover ethanol Then vacuum-dry at 40-50°C to obtain Smilax smilax extract.

[0047] (2) After detection by high performance liquid chromatography, it contains 5-O-caffeoylshikimic acid, astilbin, isoastilbin, neoastilbin, neoisoastilbin, taxifolin, astilbin, isoflavin Qilin, resveratrol. The total flavonoid content (astilbin) in the extract is 76.6%.

[0048] (3) Take 500g of Smi...

Embodiment 2

[0052] Smilax smilax lipid-lowering and weight-loss granule is prepared by the following method:

[0053] (1) Smilax smilax extract: Smilax smilax was crushed through a 40-mesh sieve, ultrasonically extracted with 10 times the volume of 60% ethanol, 60 o C recovers the ethanol in the extraction solvent under reduced pressure, and obtains the supernatant after centrifugation. Add 40-60 mesh β-cyclodextrin-starch resin with the same weight as Smilax smilax to the supernatant, oscillate and absorb for 30 minutes, then filter, and the resin is eluted twice with 60% ethanol, collect the eluate, and recover ethanol Then vacuum-dry at 40-50°C to obtain Smilax smilax extract.

[0054] (2) After detection by high performance liquid chromatography, it contains 5-O-caffeoylshikimic acid, astilbin, isoastilbin, neoastilbin, neoisoastilbin, taxifolin, astilbin, isoflavin Qilin, resveratrol. The total flavonoid content (astilbin) in the extract is 76.6%.

[0055] (3) Take 500 grams of S...

Embodiment 3

[0059] Observation on the Efficacy of the Prepared Jiangzhi Slimming Granules

[0060] Get embodiment 2 lipid-lowering and weight-reducing granules for trial use by 8 volunteers, 6 women and 2 men, with a body weight of 60-80kg. Two bags a day, 15 days of trial, during which volunteers were asked about their appetite, energy, sleep, defecation, etc., and their weight changes were recorded. Eight volunteers all reported that the trial period did not affect appetite, energy, sleep, defecation, etc., and the results of weighing all reflected that it was effective, and the weight loss range was 0.5-2 kg. typical example:

[0061] Yuan ×, female, 30 years old, weighed 65.4 kg before the trial, and reduced to 64.2 kg after 15 days of trial; after stopping the drug for 10 days, the weight remained at 64.2 kg; after taking the granule for 15 days, the weight decreased to 63.2 kg, and the drug was stopped Afterwards, the weight remained unchanged.

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Abstract

The invention belongs to the field of traditional Chinese medicines and relates to a use of rhizoma smilacis glabrae extract in preparation of lipid-lowering and fat-reducing medicines and health-care foods. The rhizoma smilacis glabrae extract comprises 5-O-caffeoylshikimic acid, astilbin, isoastilbin, neoastilbin, neoisoastilbin, taxifolin, engeletin, isoengelitin and resveratrol. An animal experiment shows that the rhizoma smilacis glabrae extract can obviously reduce mice abdominal cavity fat weight, reduce mice body weight, and reduce triglyceride and total cholesterol concentrations of mice serum. Effects of the rhizoma smilacis glabrae extract are stronger than effects of a single astilbin component. The rhizoma smilacis glabrae extract is extracted from traditional Chinese medicines, has synergism of components, has good fat-reducing effects and broadens a rhizoma smilacis glabrae application range.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the application of a traditional Chinese medicine extract in lipid-lowering and weight-loss medicines and health food. Background technique [0002] With the improvement of people's living standards, problems such as obesity and hyperlipidemia caused by excessive energy intake (high-fat, high-sugar diet) are becoming more and more serious. Obesity not only affects body shape, but more importantly, it is positively related to the incidence of diseases such as diabetes and hypertension. Hyperlipidemia is the main factor causing atherosclerosis, which may lead to various cardiovascular and cerebrovascular diseases such as thrombosis and myocardial infarction. Survey data shows that 11% of children and 30% of adults in China are overweight, and 42% of children have at least one abnormal glucose and lipid metabolism index. China is facing a sharp increase in the incidence of card...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/90A61K36/896A61P3/06A61P3/04A23L1/30A23L33/105
Inventor 张清峰付莹娟郭玉显
Owner JIANGI WENIR NUTRITION HIGH TECH
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