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A kind of preparation method and application of Zhenggu Zijin pill

A technology for bone-setting Zijin pills and leukemia is applied in the field of preparation of bone-setting Zijin pills.

Inactive Publication Date: 2015-08-19
泰州市高科新技术开发中心高港区知识产权咨询事务所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Zhenggu Zijin Pills. However, the method of making powder is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the quality of this product. clinical application

Method used

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  • A kind of preparation method and application of Zhenggu Zijin pill
  • A kind of preparation method and application of Zhenggu Zijin pill

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Take 50g of cloves, 100g of lotus seeds, 50g of cooked rhubarb, 50g of catechu, 100g of fried white peony root, 50g of dried blood, 25g of Moutan bark, 100g of angelica, 50g of woody fragrance, 100g of poria cocos, 50g of safflower, and 15g of licorice, and add them to the CO2 supercritical In the extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, and the extraction time is 150min to obtain supercritical extract powder, which is crushed into fine powder, sieved, and mixed. Add 100g of refined honey at the end of every 100g to make big honeyed pills, that is, 4.5g per pill.

Embodiment 2

[0018] Take 50g of cloves, 100g of lotus seeds, 50g of cooked rhubarb, 50g of catechu, 100g of fried white peony root, 50g of dried blood, 25g of Moutan bark, 100g of angelica, 50g of woody fragrance, 100g of Poria cocos, 50g of safflower, and 15g of licorice into CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, and the extraction time is 180min to obtain supercritical extract powder, which is crushed into fine powder, sieved, and mixed. Add 110g of refined honey at the end of every 100g to make big honeyed pills, that is, 4.5g per pill.

Embodiment 3

[0020] Take 50g of cloves, 100g of lotus seeds, 50g of cooked rhubarb, 50g of catechu, 100g of fried white peony root, 50g of dried blood, 25g of Moutan bark, 100g of angelica, 50g of woody fragrance, 100g of Poria cocos, 50g of safflower, and 15g of licorice into CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, and the extraction time is 160min to obtain supercritical extract powder, which is crushed into fine powder, sieved, and mixed. Add 100g of refined honey at the end of every 100g to make big honeyed pills, that is, 4.5g per pill.

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Abstract

The invention provides a preparing method of bone setting zijin pills. Cloves of 50g, lotus nuts of 100g, cooked rhubarb of 50g, catechu of 50g, stir-baked white paeony roots of 100g, sanguis draconis of 50g, moutan bark of 25g, Chinese angelica of 100g, elecampane of 50g, poria cocos of 100g, flos carthami of 50g and liquorice of 15g are used as raw materials to prepare the bone setting zijin pills. The bone setting zijin pills are formed through supercritical extraction, so that the content is greatly improved, and the dose is lowered. The invention further provides an application of the bone setting zijin pills in preparing medicine for inhibiting mice leukemia L1210 cell proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Zhenggu Zijin Pills. Background technique [0002] Zhenggu Zijin Wan is recorded in the drug standard WS3-B-0050-89 issued by the Ministry of Health. The prescription is 50g of cloves, 100g of lotus seeds, 50g of cooked rhubarb, 50g of catechu, 100g of fried white peony root, 50g of dried blood, 25g of Moutan bark, 100g of angelica, Crush 50g of woody fragrance, 100g of poria cocos, 50g of safflower, 15g of licorice, and the above twelve flavors into fine powder, sieve, and mix well; add 100-110g of refined honey to each 100g of powder to make a honeyed pill. Can promote blood circulation and remove blood stasis, reduce swelling and relieve pain. For bruises, blocked meridians, blood stasis, swelling and pain. [0003] In the prior art, there is no report on the use of supercritical technology in the extr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/896A61K36/889A61P35/02
Inventor 张关莲
Owner 泰州市高科新技术开发中心高港区知识产权咨询事务所
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