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Preparation method and application of Zuogui pill

A technology of Zuogui Pills and Cuscuta, which is applied in the field of preparation of Zuogui Pills, can solve the problems of large dosage, many impurities, and backwardness of patients, and achieve the effect of reducing dosage

Inactive Publication Date: 2014-01-29
张关莲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Zuogui Pills. However, the method of making powder is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the quality of this product. clinical application

Method used

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  • Preparation method and application of Zuogui pill
  • Preparation method and application of Zuogui pill

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Take rehmannia glutinosa 200g, dodder seed 100g, achyranthes bidentata 75g, tortoise shell glue 100g, deer horn glue 100g, yam 100g, dogwood 100g, medlar 100g, and add them to CO2 supercritical extractor, ethanol as entrainer, entrainer accounted for the total extraction solvent The volume percentage is 4%, extraction pressure is 15MPa, temperature is 30°C, CO 2 The flow rate is 1m1 / g crude drug·min, and the extraction time is 150min to obtain supercritical extract powder, which is crushed into fine powder, sieved, and mixed. Add 100g of refined honey at the end of every 100g to make big honeyed pills, that is, 4.5g per pill.

Embodiment 2

[0018] Take rehmannia glutinosa 200g, dodder 100g, achyranthes bidentata 75g, tortoise shell glue 100g, deer horn glue 100g, yam 100g, dogwood 100g, medlar 100g and add to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, and the extraction time is 180min to obtain supercritical extract powder, which is crushed into fine powder, sieved, and mixed. Add 110g of refined honey at the end of every 100g to make big honeyed pills, that is, 4.5g per pill.

Embodiment 3

[0020] Take rehmannia glutinosa 200g, dodder 100g, achyranthes bidentata 75g, tortoise shell glue 100g, deer horn glue 100g, yam 100g, dogwood 100g, medlar 100g and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, and the extraction time is 160min to obtain supercritical extract powder, which is crushed into fine powder, sieved, and mixed. Add 120g of refined honey at the end of every 100g to make big honeyed pills, that is, 4.5g per pill.

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Abstract

The invention provides a preparation method of a Zuogui pill. The Zuogui pill is prepared from the following crude medicines: 200g of prepared rehmannia root, 100g of seed of Chinese dodder, 75g of root of bidentate achyranthes, 100g of glue of tortoise plastron, 100g of deer-horn glue, 100g of yam, 100g of dogwood and 100g of medlar through supercritical extraction. So that content of the Zuogui pill is greatly improved and dosage is reduced. Furthermore, the invention provides an application of the Zuogui pill in preparing a medicine for inhibiting mice lung cancer Lewis cell proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Zuogui Pills. Background technique [0002] Zuogui Wan is recorded in the drug standard WS3-B-0053-89 issued by the Ministry of Health. The prescription is Rehmannia glutinosa 200g, Cuscuta 100g, Achyranthes bidentata 75g, tortoise shell glue 100g, deer horn glue 100g, yam 100g, dogwood 100g, medlar 100g, and more Eight flavors, except for antler glue and tortoise shell glue, the other six flavors such as Rehmannia glutinosa are crushed into fine powder, sieved and mixed. Take deer horn glue and tortoise shell glue to melt, and mix with the above fine powder. For every 100g of powder, add 10g of refined honey and appropriate amount of water, make pills, and dry to obtain. Can nourish the kidney and nourish yin. It is used for deficiency of true yin, sore waist and knees, night sweats and nocturnal emissi...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/20A61P1/14A61P15/00A61P35/00A61K35/32A61K35/56A61K35/586
Inventor 张关莲
Owner 张关莲
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