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Compositions and methods for the treatment and prevention of cardiac ischemic injury

A technology for cardiac ischemia and cardiac injury, which can be used in drug combinations, gene therapy, cardiovascular system diseases, etc.

Inactive Publication Date: 2014-01-29
RUTGERS THE STATE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Although surgical or pharmacological interventions are used clinically to reestablish cardiac blood flow and to treat arrhythmias and infarction-related remodeling, surprisingly there is currently no prevention or mitigation of IR-induced myocardial damage, especially cardiomyocyte damage and death Treatment

Method used

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  • Compositions and methods for the treatment and prevention of cardiac ischemic injury
  • Compositions and methods for the treatment and prevention of cardiac ischemic injury
  • Compositions and methods for the treatment and prevention of cardiac ischemic injury

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Embodiment Construction

[0222] Discovery of the muscle-specific TRIM family protein MG53. MG53 was isolated using a previously established immuno-proteomic approach that allowed the identification of proteins involved in myogenesis, Ca 2+ Novel proteins for signaling and maintenance of membrane integrity in striated muscle cells. Briefly, the method uses a monoclonal antibody library comprising -6500 clones generated from mice immunized with triad-enriched membranes from rabbit skeletal muscle. Antibodies of interest were selected based on the z-line staining pattern of striated muscle sections observed under immunofluorescence microscopy. The target protein is purified by antibody-affinity column, and the partial amino acid sequence of the purified protein is obtained. Based on this partial amino acid sequence, a complete cDNA encoding a target gene is isolated from a skeletal muscle cDNA library. The identified genes were then searched for the presence of different isoforms in other excitable ti...

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Abstract

Disclosed herein are compositions and methods for the treatment and / or prevention of pathological conditions associated with ischemia / reperfusion injury and / or hypoxic injury of myocardial cell or tissue.

Description

[0001] Cross References to Related Applications [0002] This application is a continuation-in-part of PCT / US2011 / 030703, filed March 31, 2011, which is a continuation-in-part of U.S. Patent Application Serial No. 12 / 307,303, filed January 2, 2009; claimed on July 11, 2007 PCT / US2007 / 015815, filed on July 11, 2006; and 60 / 876,871, filed December 22, 2006; and U.S. Patent Application Serial No. 12 / 328,646, filed December 4; which claims the benefit of U.S. Provisional Application 61 / 005,410, filed December 4, 2007; the contents of which are hereby incorporated by reference in their entirety for all purposes . [0003] incorporated by reference [0004] Electronic file name: Weisleder2011_ST25.txt created March 31, 2011 using Patent-In 3.5 and Checker 4.4.0, pursuant to 37 C.F.R. §1.52(e)(5), the sequence information contained in Weisleder2011_ST25.txt is incorporated by reference in its entirety into this article. [0005] Statement Regarding Federally Funded Research ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K38/16A61K48/00A61K31/7105A61P9/00
CPCA61K38/177A61K31/7135A61K31/7105A61K48/00A61K38/1709A61K31/7088A61K45/06A61P9/00A61P9/10A61K2300/00
Inventor 诺厄·魏斯勒德麻建杰
Owner RUTGERS THE STATE UNIV
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