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Use of a hypoallergenic cereal composition for inducing specific oral tolerance

A specific, grain-based technology that can be used in drug combinations, medical preparations containing active ingredients, allergic diseases, etc., and can solve problems such as allergies

Inactive Publication Date: 2014-02-12
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is generally accepted that infants with cow's milk allergy are at increased risk of developing atopy and other food proteins such as eggs and cereal proteins, however, even with oral tolerance to cow's milk proteins when these foods are introduced into the diet at weaning of those infants are also likely to subsequently develop allergies to other food proteins such as eggs and cereal proteins

Method used

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  • Use of a hypoallergenic cereal composition for inducing specific oral tolerance
  • Use of a hypoallergenic cereal composition for inducing specific oral tolerance
  • Use of a hypoallergenic cereal composition for inducing specific oral tolerance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] 10 Kg of rice flour (pretreated according to US Patent No. 4,374,860 to partially hydrolyze the carbohydrate content) and 23 kg of water were mixed and heated at 55°C. Prepare buffer solution (Na(OH) 2 or K(OH) 2 or Ca(OH) 2 ), added to the mixture for pH adjustment. Add 5% Enzyme (Lot No. PW2A1006, Novozymes A / S Bagsvaerd, Denmark), the mixture was maintained at 55°C for 2 hours. After completion of this first hydrolysis step, the mixture was heated at 90° C. for 10 minutes. Cool the mixture to 55°C, add 5% 1000 L of enzyme (Lot No. 400904, Novozymes A / S Bagsvaerd, Denmark), the mixture was maintained at 55°C for 2 hours. After this second step of hydrolysis, the mixture was heated at 90°C for 30 minutes, followed by spray drying to obtain a powder containing partially hydrolyzed rice protein with a DH of 14.2%, which was placed in an aluminum bag.

Embodiment 2

[0073] 10 Kg of rice flour (pretreated according to US Patent No. 4,374,860 to partially hydrolyze the carbohydrate content) and 23 kg of water were mixed and heated at 55°C. Prepare buffer solution (Na(OH) 2 or K(OH) 2 or Ca(OH) 2 ), the mixture was added for pH adjustment (to pH 7.8). Add 10% of Enzyme (Lot No. 500357, Novozymes A / S Bagsvaerd, Denmark), the mixture was maintained at 55°C for 2 hours. After completion of this first hydrolysis step, the mixture was heated at 90° C. for 10 minutes. The mixture was cooled to 55°C, 10% Alcalase enzyme was added, and the mixture was maintained at 55°C for 2 hours. After this second step of hydrolysis, the mixture was heated at 90°C for 30 minutes, followed by spray drying to obtain a powder containing partially hydrolyzed rice protein with a DH of 15.9%, which was placed in an aluminum bag.

Embodiment 3

[0075]10 Kg of rice flour (pretreated according to US Patent 4,374,860 to partially hydrolyze the carbohydrate content) and 23 kg of water were mixed and heated at 55°C. Prepare buffer solution (Na(OH) 2 or K(OH) 2 or Ca(OH) 2 ), the mixture was added for pH adjustment (to pH 7.8). Add 5% Enzyme (Lot No. 500357, Novozymes A / S Bagsvaerd, Denmark), the mixture was maintained at 55°C for 2 hours. After completion of this first hydrolysis step, the mixture was heated at 90° C. for 10 minutes. Cool the mixture to 55°C, add 5% Enzyme (Lot No. PW2A1006, Novozymes A / S Bagsvaerd, Denmark), the mixture was maintained at 55°C for 2 hours. After this second step of hydrolysis, the mixture was heated at 90 °C for 30 minutes, followed by spray drying to obtain a powder containing partially hydrolyzed rice protein with a DH of 11.2%, which was placed in an aluminum bag.

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Abstract

A partial hydrolysate of cereal protein for use in inducing specific oral tolerance in a young mammal with allergy to said cereal protein, wherein the hydrolysate has a degree of hydrolysis between 9 and 18%, is disclosed.

Description

field of invention [0001] The present invention relates to the use of a hypoallergenic cereal composition for inducing specific oral tolerance to cereals, especially to wheat or rice, in young mammals to which they have an IgE-mediated allergy. Background of the invention [0002] The first food allergy to occur in life is a milk allergy, which in many cases is caused by a reaction to proteins in food. Early in life, the immune system is still developing and may fail to establish tolerance to food antigens (this may also be referred to as insufficient induction of oral tolerance). The result is that the infant or young animal has an exaggerated immune response to the food protein, resulting in an allergic reaction to it. Food allergies don't just affect humans, but can also affect other mammals, such as dogs and cats. [0003] Typically, food hypersensitivity reactions occur when a susceptible or at-risk infant, child, or young animal is first exposed to a new food contain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K38/11A61P37/08A61K36/88A61K36/8998A61K38/095
CPCA61K36/899A61K39/00A61K38/011A61P37/08
Inventor A·梅赛尼尔G·奥尔特加
Owner NESTEC SA
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