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A kind of norcantharidin sodium injection and preparation method thereof

A technology of norcantharidin sodium and norcantharidin is applied in the directions of pharmaceutical formulations, inactive medical preparations, antitumor drugs, etc., and can solve the problem of poor stability of norcantharidin sodium injection and unsatisfactory long-term experimental results. , acceleration, etc.

Active Publication Date: 2016-10-05
无锡紫杉药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] It is generally believed that the pH value of the drug suitable for human injection should be controlled at 4 to 9. However, it has been proved by experiments that the stability of sodium norcantharidate injection in this pH range is poor, and the results of accelerated and long-term experiments are not ideal.

Method used

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  • A kind of norcantharidin sodium injection and preparation method thereof
  • A kind of norcantharidin sodium injection and preparation method thereof
  • A kind of norcantharidin sodium injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 5g of sodium hydroxide to 1500ml of water for injection to prepare a solution, add 10g of norcantharidin and stir to dissolve, adjust the pH to 9.1-9.5 with sodium hydroxide, add water for injection until the volume of the solution is 2000ml, add 0.01% of the drug to the prepared solution Use activated carbon, stir at room temperature for 20 minutes, filter to remove carbon, and then fine filter the filtrate through a 0.22 μm microporous membrane.

Embodiment 2

[0035] Add 5g of sodium hydroxide to 1500ml of water for injection to prepare a solution, add 10g of norcantharidin and stir to dissolve, adjust the pH to 9.3 with potassium hydroxide, add water for injection until the volume of the solution is 2000ml, add 0.01% to the prepared solution Activated carbon, stirred at room temperature for 20 minutes, filtered to remove carbon, and the filtrate was fine-filtered through a 0.22 μm microporous membrane.

Embodiment 3

[0037] Add 5g of sodium hydroxide to 1500ml of water for injection to prepare a solution, add 10g of norcantharidin and stir to dissolve, adjust the pH to 9.5 with sodium hydroxide, add water for injection until the volume of the solution is 2000ml, add 0.01% medicinal Activated carbon, stirred at room temperature for 20 minutes, filtered to remove carbon, and the filtrate was fine-filtered through a 0.22 μm microporous membrane.

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Abstract

The invention discloses a norcantharidin sodium injection and a preparation method thereof. The norcantharidin sodium injection includes norcantharidin sodium, an alkaline pH regulator and water for injection, and is characterized in that the pH value of the norcantharidin sodium injection is greater than 9.0 and less than or equal to 9.5 . The norcantharidin sodium injection of the present invention has good stability, and has the advantages of high purity and good appearance, and has good clinical application prospects.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a norcantharidin sodium injection and a preparation method thereof. Background technique [0002] In the existing rail transit platform door control system, the central control device adopts a large-scale PLC to design the door unit controller; the interface programming is inconvenient and other disadvantages. [0003] Cantharidin is an anti-tumor active ingredient extracted from the traditional Chinese medicine Mylabris. It was tried to be used for primary liver cancer in the 1970s, but its application was limited due to its strong stimulating effect on the urinary system. Sodium norcantharidinate is a derivative of cantharidin, which is a sodium salt formed by removing two methyl groups of cantharidin and hydrolyzing it. The molecular formulas of cantharidin, norcantharidin and norcantharidin sodium are as follows respectively: [0004] [0005] Sodium ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/34A61K47/04A61P35/00
Inventor 史健飞张勇朱震李春洲
Owner 无锡紫杉药业股份有限公司