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Preparation method and application of angelica sinensis and radix paeoniae alba liujun pill

A technology of Angelica and Radix Paeoniae Alba, applied in the field of preparation of Guishao Liujun Pills, can solve the problems of large dosage for patients, rough process, and affecting the application of this product, and achieve the effect of reducing the dosage

Active Publication Date: 2014-02-26
山东天成钢结构有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Guishao Liujun Pills. However, the method of powdering is rough, backward, and has many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the This product is used clinically

Method used

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  • Preparation method and application of angelica sinensis and radix paeoniae alba liujun pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 100g of angelica, 100g of fried Atractylodes macrocephala, 100g of Codonopsis pilosula, 100g of white peony root, 100g of poria cocos, 50g of roasted licorice, 50g of tangerine peel, and 50g of ginger pinellia, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, mixed evenly, and 30g of ginger and 30g of jujube are mashed, decocted, pan-pilled, and dried to obtain , Each 16 grains weighs 1g.

Embodiment 2

[0018] Take 100g of angelica, 100g of fried Atractylodes macrocephala, 100g of Codonopsis pilosula, 100g of white peony root, 100g of poria cocos, 50g of roasted licorice, 50g of tangerine peel, and 50g of ginger pinellia, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, mixed evenly, and 30g of ginger and 30g of jujube are mashed, decocted into juice, rolled into pills, and dried to obtain , Each 16 grains weighs 1g.

Embodiment 3

[0020] Take 100g of angelica, 100g of fried Atractylodes macrocephala, 100g of Codonopsis pilosula, 100g of white peony root, 100g of poria cocos, 50g of roasted licorice, 50g of tangerine peel, and 50g of ginger pinellia, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained, which is crushed into fine powder, sieved, mixed evenly, and 30g of ginger and 30g of jujube are mashed, decocted in juice, rolled into pills, and dried to obtain , Each 16 grains weighs 1g.

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Abstract

The invention provides a preparation method of an angelica sinensis and radix paeoniae alba liujun pill. The angelica sinensis and radix paeoniae alba liujun pill is prepared from 100g of angelica sinensis, 100g of fried white atractylodes rhizome, 100g of codonopsis pilosula, 100g of radix paeoniae alba, 100g of poria cocos, 50g of honey-fried licorice root, 50g of pericarpium citri reticulatae and 50g of ginger processed pinellia which are used as crude drugs by adopting supercritical extraction. Thus, the content is greatly improved, and the dose is reduced. The invention also provides application of the angelica sinensis and radix paeoniae alba liujun pill in preparation of a medicine for inhibiting cell proliferation of human melanoma cells (MV3).

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Guishao Liujun Pills. Background technique [0002] Guishao Liujun Pills are recorded in the standard WS3-B-0242-90 of the Ministry of Health. The prescription is 100g of Angelica, 100g of Stir-fried Atractylodes Rhizoma Atractylodes Rhizome, 100g of Codonopsis Radix, 100g of Radix Paeoniae Alba, 100g of Poria, 50g of Roasted Licorice, 50g of Tangerine Peel, 50g of Ginger Pinellia, and the above eight flavors , crushed into fine powder, sieved, mixed evenly, another 30g of ginger and 30g of jujube were mashed, decocted, pan-balled, dried, and obtained. Can benefit qi and nourish blood. For disharmony between the liver and spleen, abdominal distension and abdominal pain, lack of food and body fatigue, and vomiting. [0003] In the prior art, there is no report on the use of supercritical technology in the ...

Claims

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Application Information

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IPC IPC(8): A61K36/8888A61K9/20A61P35/00
Inventor 李强
Owner 山东天成钢结构有限公司
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