A kind of refining method of abamectin

A technology of abamectin and its refining method, which is applied in the field of biology and medicine, can solve the problems of large toluene loss, environmental pollution, and difficulty in concentration, and achieve the effects of ensuring health, reducing environmental pollution, and improving the working environment

Active Publication Date: 2016-06-15
NINGXIA QIYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. The extraction agent used - toluene has a high boiling point, difficulty in concentration, long time at high temperature, high energy consumption and thermal damage to the product
[0005] 2. The extraction agent used—toluene is a carcinogen, and a small amount of gas will inevitably volatilize during the operation, which will cause damage to the on-site employees and pollute the environment
[0006] 3. The extraction agent used - toluene has a large loss and the cost increases
[0007] 4. The effect of impurity removal cannot be guaranteed. In case of special circumstances, some batches of materials cannot be separated, and impurities cannot be removed. The subsequent crystallization effect is poor, resulting in poor quality of the final product

Method used

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  • A kind of refining method of abamectin
  • A kind of refining method of abamectin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take the abamectin fermentation broth, and use a plate frame to separate the solid from the liquid to obtain solid wet mycelium containing abamectin, and the filtrate that does not contain abamectin is sent for environmental protection treatment. The wet mycelium is flash-dried to remove more than 60% of the water to obtain dry mycelium, and the avermectin in the dry mycelia is extracted and dissolved in methanol, and the dried mycelium after extraction is mixed with methanol solution to form a methanol extraction mixture Liquid, the methanol extraction mixture is then separated from the solid and liquid by the dark flow plate frame, the liquid is the methanol extraction solution, and the solid phase is the waste mycelium that does not contain abamectin. The waste mycelium is washed with water to remove residual methanol and sent to environmental protection. The methanol extract is concentrated to remove methanol to obtain the methanol concentrate of abamectin, then add ...

Embodiment 2

[0020] Take the abamectin fermentation broth, and use a plate frame to separate the solid from the liquid to obtain solid wet mycelium containing abamectin, and the filtrate that does not contain abamectin is sent for environmental protection treatment. The wet mycelium is flash-dried to remove more than 60% of the water to obtain dry mycelium, and the avermectin in the dry mycelia is extracted and dissolved in methanol, and the dried mycelium after extraction is mixed with methanol solution to form a methanol extraction mixture Liquid, the methanol extraction mixture is then separated from the solid and liquid by the dark flow plate frame, the liquid is the methanol extraction solution, and the solid phase is the waste mycelia that does not contain abamectin. The waste mycelium is washed with water to remove residual methanol and then sent to environmental protection. The methanol extract is concentrated to remove methanol to obtain the methanol concentrate of abamectin, and t...

Embodiment 3

[0022] Take the abamectin fermentation broth, and use a plate frame to separate the solid from the liquid to obtain solid wet mycelium containing abamectin, and the filtrate that does not contain abamectin is sent for environmental protection treatment. After the wet mycelium is flash-dried to remove more than 60% of the water, the dry mycelium is obtained. The avermectin in the dry mycelia is extracted and dissolved in methanol, and the dried mycelium after extraction is mixed with methanol solution to form a methanol extraction mixture. Liquid, the methanol extraction mixture is then separated from the solid and liquid by the dark flow plate frame, the liquid is the methanol extraction solution, and the solid phase is the waste mycelia that does not contain abamectin. The waste mycelium is washed with water to remove residual methanol and then sent to environmental protection. The methanol extract is concentrated to remove methanol to obtain the methanol concentrate of abamec...

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PUM

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Abstract

The invention relates to a method for refining abamectin, comprising plate and frame filtration of abamectin fermentation liquid, flash drying, adding methanol to form a methanol extract, concentration, impurity removal treatment and crystallization, characterized in that The impurity removal treatment is to add hot water at a temperature of 70-80°C to the concentrated methanol concentrate, stir thoroughly for 30-60 minutes, then cool down to room temperature, stand for stratification, and remove the upper layer of water layer. Crystallization treatment. The present invention adopts the water washing method to remove sugar and impurities, and because toluene is no longer used in the refining process, the cost of raw materials is reduced by 10%; the crystallization yield is increased from 65% to 70%, and the improvement rate is 7.7%; the quality of abamectin is stable, and the finished product All meet the national standard requirements and synthesis needs; the on-site working environment has been greatly improved to fully protect the health of employees and reduce environmental pollution.

Description

technical field [0001] The invention relates to the technical field of biology and medicine, in particular to a method for refining abamectin. Background technique [0002] Abamectin is a group of insecticidal antibiotics composed of a sixteen-membered macrolide and a diolean fructose produced by the fermentation of Streptomyces avermanii. It has a unique effect, and its derivatives such as emamectin benzoate are new types of insecticides that are safer, more efficient, and have a wider insecticidal spectrum, which greatly broadens the use of abamectin scope. It shows a trend of gradually replacing abamectin in the market. However, due to fluctuations in the quality control of various manufacturers in the refining process, there are large differences in the quality of the produced avime powder, which has a great impact on the subsequent synthesis of derivatives. How to improve the Avi refining process and ensure product quality is an urgent problem for manufacturers. [...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/08C07H1/08
Inventor 范天东孙瑞君陈凤琴张志
Owner NINGXIA QIYUAN PHARMA
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