Traditional Chinese medicine granule for treating side effects on alimentary canal after cancer chemotherapy and preparation method thereof

A technology of traditional Chinese medicine granules and digestive tract, applied in the digestive system, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as decreased compliance, death, malnutrition, etc., to improve vomiting symptoms, inhibit tumor growth, The effect of reducing the number of vomiting

Inactive Publication Date: 2014-03-12
辽宁省中医药研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acute and severe nausea and vomiting can lead to dehydration, electrolyte imbalance, and malnutrition in patients. In severe cases, bleeding, infection, and even death may occur due to damage to the digestive tract mucosa, which makes patients fear chemotherapy and significantly reduces compliance, which seriously affects the therapeutic effect. and patient quality of life

Method used

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  • Traditional Chinese medicine granule for treating side effects on alimentary canal after cancer chemotherapy and preparation method thereof
  • Traditional Chinese medicine granule for treating side effects on alimentary canal after cancer chemotherapy and preparation method thereof
  • Traditional Chinese medicine granule for treating side effects on alimentary canal after cancer chemotherapy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Influence of traditional Chinese medicine granules for treating digestive tract side effects after cancer chemotherapy on cisplatin-induced domestic pigeon emesis model

[0015] Drug raw materials include: Astragalus 700g, Ophiopogon japonicus 250g, Red ginseng 230g, Bran fried Atractylodes macrocephala 250g, Poria cocos 240g, Licorice 250g, Scrophulariaceae 250g, Angelica 270g, Black plum 250g, Pinellia 340g, Patchouli 210g, Chenpi 300g, Curcuma 240g; 50% ethanol 300ml; sucrose 650g.

[0016] Stir-fry Atractylodes macrocephala, angelica, patchouli, tangerine peel and zedoary with 5 times the amount of water, soak for 4 hours, extract the volatile oil for 5 hours, collect the volatile oil, and save it for later use; filter the distilled aqueous solution, and store it in another container; Winter, red ginseng, poria cocos, licorice, scrophulariaceae, ebony, and pinellia, add water and decoct 3 times, add 6 times the amount of water each time, extract for 2 hours, filter,...

Embodiment 2

[0028] Traditional Chinese medicine granules for the treatment of digestive tract side effects after cancer chemotherapy 180 Effects of tumor weight and tumor inhibition rate on mice with solid tumors

[0029]The raw materials of the medicine include: 790g of Astragalus, 300g of Ophiopogon japonicus, 240g of red ginseng, 220g of bran fried Atractylodes, 250g of Poria, 210g of licorice, 280g of Scrophulariaceae, 210g of Angelica, 320g of ebony, 270g of French pinellia, 270g of patchouli, 270g of dried tangerine peel, Curcuma 210g; 75% ethanol 550ml; dextrin 500g; lactose 500g.

[0030] Add 8 times the amount of water to bran fried Atractylodes, Angelica, Patchouli, Chenpi and Curcuma, soak for 1 hour, extract the volatile oil for 6 hours, collect the volatile oil and save it for later use; filter the distilled water solution and save it in another container; the residue is mixed with astragalus, wheat Winter, red ginseng, Poria, licorice, Scrophulariaceae, ebony, and Pinellia ...

Embodiment 3

[0043] Effects of traditional Chinese medicine granules for the treatment of gastrointestinal side effects after cancer chemotherapy on serum hemolysin production in CTX-induced immunocompromised mice

[0044] The raw materials of the medicine include: 650g of Astragalus, 330g of Ophiopogon japonicus, 160g of red ginseng, 170g of bran fried Atractylodes, 160g of Poria, 290g of Licorice, 210g of Scrophulariaceae, 250g of Angelica, 300g of ebony, 300g of French Pinellia, 290g of Patchouli, 220g of dried tangerine peel, Curcuma 270g; 90% ethanol 850ml; dextrin 1400g.

[0045] Add 6 times the amount of water to the bran fried Atractylodes, Angelica, Patchouli, Chenpi and Curcuma, soak for 2 hours, extract the volatile oil for 4 hours, collect the volatile oil, save it for later use; filter the distilled aqueous solution, and save it in another container; the residue is mixed with astragalus, wheat Winter, red ginseng, Poria, licorice, Scrophulariaceae, ebony, and Pinellia sinensis...

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Abstract

The objective of the invention is to provide a traditional Chinese medicine granule for treating side effects on an alimentary canal after cancer chemotherapy and a preparation method thereof. The invention is characterized in that the granule is prepared from an active component, a binder and pharmaceutically acceptable adjuvant, and the active component is prepared from the traditional Chinese medicines consisting of 600 to 800 g of milkvetch root, 250 to 350 g of dwarf lilyturf tuber, 150 to 250 g of red ginseng, 150 to 250 g of white atractylodes rhizome fried with bran, 150 to 250 g of Poria cocos, 200 to 300 g of licorice, 200 to 300 g of radix scrophulariae, 200 to 300 g of Chinese angelica, 250 to 350 g of dark plum, 250 to 350 g of prepared pinellia tuber, 200 to 300 g of cablin patchouli herb, 200 to 300 g of dried orange peel and 200 to 300 g of curcuma rhizome. The granule is applicable to cancer patients who vomit or retch because of damage of both qi and yin and rising of stomach qi resulting from damage of the spleen and the stomach by anti-radiogenic cancer and chemotherapy drugs, and the granule can mitigate symptoms like no appetite, tiredness, hypodynamia, a red or light red tongue with little fluid and weak pulse.

Description

technical field [0001] The invention belongs to the technical field of Chinese herbal medicines, and particularly provides a Chinese medicine granule for treating side effects of digestive tract after cancer chemotherapy and a preparation method thereof. Background technique [0002] Cancer is a disease that seriously threatens human health, and its mortality rate ranks first among various diseases. Chemotherapy is one of the main treatment methods, but most chemotherapy drugs often cause symptoms such as nausea, vomiting, and loss of appetite during treatment, which is called Chemotherapy-induced nausea and vomiting (CINV). Acute and severe nausea and vomiting can lead to dehydration, electrolyte imbalance, and malnutrition in patients. In severe cases, bleeding, infection, and even death may occur due to damage to the digestive tract mucosa, which makes patients fear chemotherapy and significantly reduces compliance, which seriously affects the therapeutic effect. and pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/16A61P1/08A61P1/14A61P35/00A61P37/04
Inventor 王玉琢贾冬尤献民
Owner 辽宁省中医药研究院
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