Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of antiviral oral liquid

An antiviral oral liquid and solution technology, applied in the field of medicine, can solve the problems of affecting the original curative effect of the product, unacceptable to children, poor stability of the finished product, etc., and achieve the effects of increasing the content, improving the curative effect and improving the stability.

Active Publication Date: 2015-11-11
郑州大明药物科技有限公司
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the stability of the finished product is relatively poor, which may affect the original curative effect of the product; and because the volatile oil has a strong pungent taste, which affects the taste, it is difficult for children to accept

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of antiviral oral liquid
  • Preparation method of antiviral oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation method of antiviral oral liquid of the present invention, its detailed steps are as follows:

[0028] a, pretreatment: according to the composition of reed root 400g, rehmannia glutinosa 200g, turmeric 175g, Shichangpu 175g, Radix Radix 900g, Patchouli 225g, Anemarrhena 175g, Forsythia 350g and gypsum 400g, take various raw materials, The various raw materials are pulverized separately, and then passed through a 5-10 mesh sieve, and the sieved medicinal powder is mixed uniformly to obtain a mixed medicinal powder;

[0029] b. Extraction: Add water 8 times the weight of the mixed medicinal powder to the mixed medicinal powder pretreated in step a, heat to boiling, extract by steam distillation for 3 hours, then obtain 23.7 mL of volatile oil and 1943 mL of extract by an oil-water separator; The slag was added with water 5 times the weight of the mixed medicinal powder again, decocted for 2 hours, filtered to obtain an extract, and the extract obtained twi...

Embodiment 2

[0035] The preparation method of antiviral oral liquid of the present invention, its detailed steps are as follows:

[0036] a, pretreatment: according to the composition of reed root 400g, rehmannia glutinosa 200g, turmeric 175g, Shichangpu 175g, Radix Radix 900g, Patchouli 225g, Anemarrhena 175g, Forsythia 350g and gypsum 400g, take various raw materials, The various raw materials are pulverized separately, and then passed through a 5-10 mesh sieve, and the sieved medicinal powder is mixed uniformly to obtain a mixed medicinal powder;

[0037] b. Extraction: Add water 8 times the weight of the mixed medicinal powder to the mixed medicinal powder pretreated in step a, heat to boiling, extract by steam distillation for 3 hours, then obtain 23.7 mL of volatile oil and 1943 mL of extract by an oil-water separator; The slag was added with water 5 times the weight of the mixed medicinal powder again, decocted for 2 hours, filtered to obtain an extract, and the extract obtained twi...

Embodiment 3

[0042] Embodiment 3: basically the same as Embodiment 1, the difference is:

[0043] In step d: Dissolve 25mL of anhydrous volatile oil, 40g of lecithin, and 20g of cholesterol in 120mL of ethanol, and slowly inject the solution into 500mL of water at 50°C through a syringe under stirring, at a stirring speed of 260r / min, and continue stirring for 2 hours after the injection is completed Make ethanol volatilization completely; After cooling to room temperature, volatile oil liposome solution is obtained, and the encapsulation efficiency is 96.1%;

[0044] In step e: adjust the pH value to 5.0 with a sodium hydroxide solution with a concentration of 10% by mass;

[0045] In step f: detection by gas chromatography, each 10 mL of antiviral oral liquid contains 43.5 μg of patchouli alcohol.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of antivirus oral liquid. The preparation method comprises the following steps: firstly crushing reed rhizome, radix rehmanniae, radix curcumae, rhizoma acori graminei, radix isatidis, pogostemon cablin, rhizoma anemarrhenae, forsythia and gypsum, uniformly mixing, extracting by using a water vapor distillation method, separating so as to obtain volatile oil and an extracting solution; concentrating the extracting solution, dehydrating the volatile oil, dissolving and treating the dehydrated volatile oil, phospholipid and cholesterol in a solvent so as to obtain a volatile oil liposome solution; adding auxiliary materials to the concentrated solution, adjusting the pH value, then adding the volatile oil liposome solution to the concentrated solution for fixing the volume, filtering so as to obtain the antivirus oral liquid, finally filling and sterilizing. According to the preparation method, liposome is used for encapsulating the volatile oil, so that the encapsulation efficiency is relatively high, and the encapsulation rate can reach about 95%. The preparation method is used for preparing the antivirus oral liquid and can be used for obviously improving the stability of the volatile oil and ensuring the curative effect of a product.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation method of an antiviral oral liquid. Background technique [0002] Antiviral oral liquid is a traditional Chinese medicine preparation widely used in the market, and it is mainly used clinically for the treatment of wind-heat cold and flu. The prescription process of antiviral oral liquid in Pharmacopoeia is as follows: [0003] The formula of the existing antiviral oral liquid is 129g of isatidis, 57g of gypsum, 61g of reed root, 32g of rehmannia glutinosa, 25g of curcuma, 25g of anemarrhena, 25g of calamus, 29g of patchouli and 46g of forsythia. Its existing preparation method is: [0004] Add water to decoct the above nine herbs twice, for the first time 3 hours, collect the volatile oil, and wrap it with hydroxypropyl beta cyclodextrin, or for the first time 1.5 hours (collect the volatile oil and volatile oil emulsion at the same time); the second time Sec...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P11/00A61P31/16A61K33/06
Inventor 刘志庆王翠霞贾晓璐苗海敏王娜
Owner 郑州大明药物科技有限公司
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com