Propolis extract and application thereof

A propolis extract and extract technology are applied in the field of propolis extract, which can solve the problems of enriching anti-inflammatory and liver-protecting active ingredients, unable to effectively apply anti-inflammatory, liver-protecting nutrition health care and medicines, and having no biological activity, etc. Achieve the effect that is conducive to popularization and application, easy to implement, and obvious effect

Active Publication Date: 2014-03-26
BEE RES INST CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the extract obtained by the above-mentioned technical scheme is mainly light-colored propolis, which fails to effectively enrich anti-inflammatory and liver-protecting active ingredients, does not have good anti-inflammatory and liver-protecting biological activities, and cannot be effectively applied to anti-inflammatory, liver-protecting Nutrition and health care for the liver and the development of medicines

Method used

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  • Propolis extract and application thereof
  • Propolis extract and application thereof
  • Propolis extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A preparation method of propolis extract, the preparation method comprises the following steps successively:

[0041] 1. Weigh 401.3 g of propolis powder (containing 50% of glue) that has passed through a 120-mesh sieve after pulverization, put it in a conical flask, add 40% ethanol in a volume ratio of 1:6, and at 30 ° C, at a speed of 90 rpm Extract for 8h, add 40% ethanol at a volume ratio of 1:4, extract under the same conditions for 12h, combine the extracts, filter, and concentrate under reduced pressure as the 40% extract in the test example for later use.

[0042] 2. Take the residue obtained in step 1, add 70% ethanol at a volume ratio of 1:6, extract at 30°C for 1 day at a rotational speed of 180 rpm, add 70% ethanol at a volume ratio of 1:4, and extract for 2 days under the same conditions , the volume ratio is 1:3, add 70% ethanol, extract under the same conditions for 3 days, combine the extracts, let stand at 4 ℃ overnight, and then carry out suction filtr...

Embodiment 2

[0045] A preparation method of propolis extract, the preparation method comprises the following steps successively:

[0046] 1. Weigh 100 g of propolis powder (containing 50% of glue) that has passed through an 80-mesh sieve after pulverization, put it in a conical flask, add 40% ethanol in a volume ratio of 1:4, and extract at 35 ° C and a rotating speed of 100 rpm. 12h, add 40% ethanol at a volume ratio of 1:3, extract under the same conditions for 4h, the extracts are combined and filtered, and concentrated under reduced pressure as the 40% extract in the test example for later use.

[0047] 2. Take the residue obtained in step 1, add 70% ethanol in a volume ratio of 1:6, extract at 40°C for 2 days at a rotational speed of 200 rpm, add 70% ethanol in a volume ratio of 1:5, and extract for 1 day under the same conditions , the volume ratio is 1:3, add 70% ethanol, extract under the same conditions for 1 day, combine the extracts, let stand at 4 ℃ overnight, and then carry ou...

Embodiment 3

[0050] A preparation method of propolis extract, the preparation method comprises the following steps successively:

[0051] 1. Weigh 500 g of propolis powder (containing 50% of glue) that has passed through an 80-mesh sieve after crushing, put it in a conical flask, add 40% ethanol at a volume ratio of 1:3, extract at 35°C and a rotating speed of 60rpm 12h, add 40% ethanol at a volume ratio of 1:4, extract under the same conditions for 6h, the extracts are combined and filtered, and concentrated under reduced pressure as the 40% extract in the test example for later use.

[0052] 2. Take the residue obtained in step 1, add 70% ethanol in a volume ratio of 1:6, extract at 40°C for 2 days at a speed of 180 rpm, add 70% ethanol in a volume ratio of 1:5, and extract for 1 day under the same conditions , the volume ratio is 1:3, add 70% ethanol, extract under the same conditions for 1 day, combine the extracts, let stand at 4 ℃ overnight, and then carry out suction filtration. Th...

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Abstract

The invention discloses an extract with the functions of inflammation prevention and liver protection, which is prepared from propolis through a great deal of process research. Strict activity experiment shows that the extract has the inhibiting effect on human leukocyte elastase and has the protection effect on liver injury caused by carbon tetrachloride. The extract can be applied to development of plant source inflammation prevention and liver protection products. At present, the propolis is utilized primitively in China. As a raw material for producing plant source inflammation prevention and liver protection products, the propolis extract which is disclosed by the invention has the advantages of high eating security and simple process. A tablet prepared from the propolis extract is simple in prescription and preparation method, stable in quality and beneficial to popularization and application.

Description

technical field [0001] The invention relates to a propolis extract, in particular to a propolis extract prepared by a specific method and its application. Background technique [0002] Propolis is a jelly-like substance prepared by bees chewing gums collected from plants, mixed with secretions from their upper frontal glands and beeswax. The chemical composition of propolis mainly includes flavonoids, terpenes, aromatic acids and esters of aromatic acids, phenols, alcohols, aldehydes, ketones, and also contains trace amounts of proteins and enzymes. At present, propolis has been confirmed to have a wide range of pharmacological activities such as antibacterial, antifungal, antiviral, anti-inflammatory, antioxidant, and anticancer. The discovery of these effects directly provides the basis for the development of special nutritional health care and medicines. [0003] Experiments have shown that propolis has a good anti-inflammatory effect. Propolis ethanol extract and prop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A23L1/076A23L1/29A61P29/00A61P1/16A23L21/20A23L33/00
Inventor 孙丽萍徐响杜夏沈新锋
Owner BEE RES INST CHINESE ACAD OF AGRI SCI
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