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Application of andrographolide C to preparation of weight-losing food or medicine

A technology of andrographolin and weight-loss food, which is applied in the application field of traditional Chinese medicine, can solve the problems of mice not having anti-obesity and insignificant weight loss, and achieve the effects of enhancing immunity, ensuring effectiveness, and promoting body health

Inactive Publication Date: 2014-05-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By comparing Table 1 in the specific embodiment, it can be seen that when mice are fed a high-fat diet, 100 mg / kg of andrographolide is mixed in the diet, and after oral treatment for one week and three weeks, the body weight of mice is the same as that of only feeding high-fat diets. Compared with mice, the body weight loss is not obvious, indicating that the andrographolide used in this patent has no anti-obesity effect on mice

Method used

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  • Application of andrographolide C to preparation of weight-losing food or medicine
  • Application of andrographolide C to preparation of weight-losing food or medicine
  • Application of andrographolide C to preparation of weight-losing food or medicine

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Effect test

Embodiment 1

[0043] Functional slimming drink containing andrographolin (according to mass fraction):

[0044] Andrographolin 0.0375%, citric acid 0.25%, honey 6%, aspartame 1.5%, food flavor 0.05%, sodium carboxymethylcellulose 1%, water 91.20%.

[0045]According to the above formula, mix 3.75 grams of andrographol, 25 grams of citric acid, 63.5 grams of honey, 150 grams of aspartame, 5 grams of edible essence, 100 grams of sodium carboxymethylcellulose, and 9120 grams of water, mix well, boil, and sterilize Fill the beverage bottle and get it. Each bottle is 200ml, and the content of andrographolide is 75mg / bottle.

[0046] Dosage for adults: 2 times a day, 1 bottle each time.

Embodiment 2

[0048] Andrographolin tablets (according to mass fraction):

[0049] Andrographolin 50%, starch 17.3%, lactose 25%, croscarmellose sodium starch 7%, magnesium stearate 0.7%.

[0050] According to the mass fraction of the above formula, 75 grams of andrographolin and 26.25 grams of starch were dissolved in 150 grams of water, and spray-dried to make andrographolin microcapsule particles. Mix the microcapsules with 37.5 grams of lactose, 10.5 grams of cross-linked carboxymethyl starch sodium and 1.05 grams of magnesium stearate, add them into a three-dimensional motion mixer, and mix for 15-20 minutes to obtain a total mixture. Then direct tableting obtains 1000 tablets altogether, each 0.15 gram, andrographolin content 75 mg / grain

[0051] Dosage for adults: Take 1 tablet 2 times a day.

[0052] Weight loss test

[0053] Test 1: observe the effect of andrographolin on the proliferation activity of 3T3-L1 preadipocytes, and understand its mechanism of inhibiting the prolifera...

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Abstract

The invention discloses an application of andrographolide C to preparation of a weight-losing food or medicine and an application of a medicine composition composed of the andrographolide C which is used as an active component and a pharmaceutically-acceptable additive to preparation of the weight-losing food or medicine. According to the application, the technical prejudices in the prior art that andrographolide does not have the weight-losing effect are overcome and an application field of the andrographolide C is expanded. A cell experiment shows that the andrographolide C can inhibit the proliferation of 3T3-L1 preadipocytes through an oxidative stress way; the preadipocytes can be effectively prevented from being differentiated to fat cells and lipids in the fat cells are promoted to be decomposed. A mouse experiment shows that the andrographolide C has obvious effects on reducing the growth rate of body mass of a mouse, the food utilization rate and the in-vivo fat, and a dosage dependency relation is formed; the mouse blood glucose level and the serum cholesterol level can be effectively reduced, and the serum free fatty acid level and the oxidation resistance level are improved.

Description

technical field [0001] The invention relates to the technical field of application of traditional Chinese medicines, in particular to the application of andrographolin in the preparation of weight loss food or medicine. Background technique [0002] Obesity refers to a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. It does not refer to simple weight gain, but the state of excess accumulation of fat tissue in the body. In recent years, both developed and developing countries are facing the problem of accelerated development of obesity, which brings huge medical costs and social burdens. Since the use of drugs to treat obesity in the 19th century, a large number of weight loss drugs have been withdrawn from the market due to safety issues, such as sibutramine, fenfluramine, dexfenfluramine, phenylpropanolamine, rimonapr, etc. In view of the increasingly serious obesity epidemi...

Claims

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Application Information

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IPC IPC(8): A23L1/29A61K31/7048A61P3/04A23L33/00
CPCA23L2/38A23L33/00A23P10/28A23V2002/00A61K9/2059A61K31/7048A23V2250/30A23V2200/332A23V2250/032A23V2250/2482A23V2250/51088A23V2250/5118A23V2250/612
Inventor 陈卫郑晓冬
Owner ZHEJIANG UNIV
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