Compound long-acting microsphere anthelmintic containing ivermectin, albendazol sulfoxide and praziquantel

A technology of ivermectin and propyl sulfide sulfoxide is applied in the field of preparation of compound anthelmintic veterinary drugs, can solve problems such as poor broad-spectrum, short duration of drug efficacy, and achieves simple equipment, great economic and social benefits, and high production efficiency. The effect of program green environmental protection

Inactive Publication Date: 2014-05-21
江苏斯威森生物医药工程研究中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] The core problem to be solved in the present invention is to overcome the shortcomings of existing antiparasitic drugs at home and abroad such as poor broad spectrum and short duration of drug effect, and to establish compound drug microspheres containing the best three antiparasitic drugs at the same time, so as to be used in Preparation of broad-spectrum, long-acting, low-toxicity and convenient-to-use antiparasitic drugs

Method used

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  • Compound long-acting microsphere anthelmintic containing ivermectin, albendazol sulfoxide and praziquantel

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Example 1 Preparation of Polylactic Acid Microspheres of Ivermectin, Propylsulfoxide and Praziquantel

[0021] In a 200 L stainless steel reactor (Reaction Tank No. 1), 100 L of deionized water and 1 kg of polylactic acid with a molecular weight of 50,000 were added in turn to dissolve at room temperature, and the stirring was continued for 10 min before use. Add dichloromethane: absolute ethanol = 7:3 to dissolve 4 L in No. 2 10 L dissolution reactor, add 200 g ivermectin, 100 g sulfoxide and 60 g praziquantel again, stir and dissolve at room temperature . Turn on the No. 1 stainless steel reaction kettle and stir at a high speed at 8000 rpm. At the same time, add the drug-containing organic phase in the No. 2 dissolution tank to the No. 1 reaction kettle dropwise at a speed of 6 mL / min. / 3 or less, add about 1 h. Continue high-speed stirring and heat to 30 °C to volatilize the organic solvent dichloromethane. After 2 hours, the dichloromethane was basically vola...

Embodiment 2

[0022] Example 2 Preparation of Polylactic Acid Microspheres of Ivermectin, Propylsulfoxide and Praziquantel

[0023] In a 200 L stainless steel reactor (Reaction Tank No. 1), 100 L of deionized water and 0.8 kg of polylactic acid with a molecular weight of 87,000 were added in turn to dissolve at room temperature, and the stirring was continued for 20 min before use. Add chloroform: absolute ethanol = 7:3 to dissolve 4 L in No. 2 10 L dissolution reactor, add 200 g of ivermectin, 100 g of sulfoxide and 60 g of praziquantel again, stir and dissolve at room temperature. Turn on the No. 1 stainless steel reaction kettle for high-speed stirring at a speed of 9000 rpm. At the same time, add the drug-containing organic phase in the No. 2 dissolution tank to the No. 1 reaction kettle dropwise at a speed of 5 mL / min. / 3 or less, it takes about 1.5 h to finish adding. Continue stirring at high speed, and heat to 30°C to volatilize the organic solvent chloroform. After 2 hours, t...

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Abstract

The invention provides a compound long-acting microsphere anthelmintic containing ivermectin, albendazol sulfoxide and praziquantel. The invention provides a process for coating a polylactic acid microsphere with ivermectin, albendazol sulfoxide and praziquantel, wherein an organic solvent containing ivermectin, albendazol sulfoxide and praziquantel is dispersed with a polylactic acid aqueous solution at high speed, and the mixture is centrifugally separated and dried in vacuum to obtain a stable drug-containing microsphere after the organic solvent is volatized. The process is simple in equipment and environmental friendly in production process, and has great economical and social benefits.

Description

technical field [0001] The invention relates to the preparation of a compound anthelmintic veterinary drug preparation, in particular to a slow-release, long-acting anti-parasitic injection prepared with ivermectin, propylsulfoxide and praziquantel as the raw materials of the veterinary drug and polylactic acid as the pharmaceutical excipient veterinary medicine. Background technique [0002] Livestock and poultry parasite drugs have always been one of the hot spots in the veterinary drug research community. The development of broad-spectrum anti-parasitic drugs with good curative effect, long-lasting effect, small side effects and no residue is a key research topic of the Ministry of Agriculture. The breeding environment of most animals in our country is poor, and animal parasites are easy to breed. After investigation, there are about 2,000 kinds of parasites, because parasitic diseases have caused huge losses to my country's animal husbandry. Nematodes and parasites cost...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/16A61K47/34A61P33/00A61K31/4985A61K31/4184
Inventor 彭学东张梅赵金召闫勇义
Owner 江苏斯威森生物医药工程研究中心有限公司
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