Biodegradable material for preventing postoperative adhesion and preparation method thereof

A degradable material and biological technology, applied in surgery, medical science, etc., can solve the problems of long preparation period and complicated operation steps, and achieve the effect of preventing adhesion, good mechanical strength, and no genotoxicity.

Active Publication Date: 2016-01-13
BEIJING DATSING BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The organic solvent introduced by this technology needs to be thoroughly cleaned to ensure the biological safety of the product. In addition, the process includes more complicated operation steps and a longer preparation cycle

Method used

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  • Biodegradable material for preventing postoperative adhesion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Biodegradable material for preventing postoperative adhesions and its preparation

[0027] Include the following steps:

[0028] (1) Sodium hyaluronate with a molecular weight of 2 million Daltons was dissolved in purified water to prepare a solution with a concentration of 2%. Stir to fully dissolve the sodium hyaluronate.

[0029] (2) Slowly add 2-chloro-1-methylpyridinium iodide (CMPI) dropwise to the sodium hyaluronate solution, so that the molar ratio of CMPI to sodium hyaluronate is 1:8, and after fully stirring and mixing, Stand at room temperature for 12h.

[0030] (3) Use dialysis paper to dialyze the mixed solution, and replace the purified water for dialysis regularly.

[0031] (4) Pour the mixed solution into a mold, and vacuum-dry for 24 hours in a temperature-changing environment of 30° C., 40° C., 45° C., and 30° C. to obtain a film-like degradable anti-adhesion material.

Embodiment 2

[0032] Example 2 Biodegradable material for preventing postoperative adhesions and its preparation

[0033] (1) Sodium hyaluronate with a molecular weight of 2 million Daltons was dissolved in purified water to prepare a solution with a concentration of 0.6%. Stir to fully dissolve the sodium hyaluronate.

[0034] (2) Slowly add water-soluble carbodiimide (EDC) dropwise to the sodium hyaluronate solution, so that the molar ratio of EDC to sodium hyaluronate is 1:5, stir and mix well, and let stand at room temperature for 8 hours.

[0035] (3) Dialyze the mixed solution with dialysis paper, and replace the purified water for dialysis every 1 hour. Cumulatively wash 12 times.

[0036] (4) Pour the mixed solution into a mold, freeze at -30° C. for 2 hours, and then dry at 25° C. for 24 hours to obtain a spongy degradable anti-adhesion material.

Embodiment 3

[0037] Example 3 Biodegradable material for preventing postoperative adhesions and its preparation

[0038] (1) Sodium hyaluronate with a molecular weight of 1.6 million Daltons was dissolved in purified water to prepare a solution with a concentration of 2%. Stir to fully dissolve the sodium hyaluronate.

[0039] (2) Slowly add 2-chloro-1-methylpyridinium iodide (CMPI) dropwise to the sodium hyaluronate solution, so that the molar ratio of CMPI to sodium hyaluronate is 1:16, and after fully stirring and mixing, Stand at room temperature for 12h.

[0040] (3) Dialyze the mixed solution with dialysis paper, replace the purified water for dialysis every 2 hours, and wash 5 times cumulatively.

[0041] (4) Pour the mixed solution into a mold, and vacuum-dry it in an environment of 40° C. for 24 hours to obtain a transparent film-like degradable anti-adhesion material.

[0042] The self-crosslinking biodegradable biomaterial prepared in Examples 1-3 has good mechanical strength, ...

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Abstract

The invention provides a biodegradable material for preventing postoperative adhesion. A method for preparing the biodegradable material comprises the steps of adding a cross-linker into a 0.5-2.5% sodium hyaluronate solution, carrying out cross-linking reaction at the temperature of 0-80 DEG C, dialyzing a mixed solution in water after the reaction is ended, and drying the dialyzed solution, thereby obtaining the biodegradable material. The degradable biological material prepared by the method has good physical and chemical properties and biocompatibility, and can be used for effectively preventing the occurrence of postoperative adhesion.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a biodegradable material for preventing postoperative adhesions and a preparation method thereof. Background technique [0002] Adhesions are a common problem after surgery, especially abdominal surgery. Postoperative adhesions can lead to serious complications such as in abdominal surgery where adhesions can lead to conditions such as intestinal obstruction, infertility and chronic pelvic pain. At present, commonly used anti-adhesion materials include polylactic acid, hyaluronic acid, chitosan, chitosan, collagen, etc. Among them, hyaluronic acid has been proven to reduce the occurrence of postoperative adhesions after abdominal surgery, so it is an ideal material for preventing postoperative adhesions. [0003] Hyaluronic acid is a heteropolysaccharide composed of alternating residues of D-glucuronic acid and N-acetyl-D-glucosamine. Under normal physiological conditions in t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/06A61L31/14
Inventor 翟晖袁源李次会李湘杰殷瑞贤
Owner BEIJING DATSING BIO TECH
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