Method for performing simulated evaluation on curative effect of multiple myeloma bone disease therapeutic method

Abstract

A method for performing simulated evaluation on the curative effect of a multiple myeloma bone disease therapeutic method includes the steps that first, according to various experimental results relevant to multiple myeloma bone disease, potential relevance between different experimental results is analyzed, and a functional block diagram relevant to the forming mechanism of the multiple myeloma bone disease is established; then, a mathematical model capable of accurately simulating mutual effects of all factors in the functional block diagram of the forming mechanism of the multiple myeloma bone disease is established, and the forming process of the multiple myeloma bone disease is simulated; finally, the mathematical model is expanded and made to be capable of describing the mechanism of action of the therapeutic method, and simulated evaluation is performed on the therapeutic method. With the method, the testing cost of the therapeutic method can be reduced, the development period of the therapeutic method can be shortened, the forming process of the multiple myeloma bone disease can be simulated more completely, the method is favorable for carrying out some medical experiments which may harm the health of the human body and thus is difficult to perform in the human body, and thus a basis is laid for thoroughly healing the multiple myeloma bone disease.

Description

technical field [0001] The invention relates to a simulation evaluation method for evaluating curative effect of multiple myeloma bone disease treatment methods, and belongs to the technical field of biomedical system modeling and simulation in biomedical engineering. Background technique [0002] Multiple myeloma is one of the most common hematologic malignancies, accounting for 10% of all hematologic malignancies. Multiple myeloma bone disease, as the most common complication of multiple myeloma, is an important cause of death in patients. According to incomplete statistics, the average survival period of patients with multiple myeloma bone disease after diagnosis is only 50 to 55 months. Multiple myeloma bone disease is still an incurable disease. Existing treatments, including bisphosphonate therapy and proteasome inhibition, can only alleviate the disease and prolong the patient's survival, but cannot completely cure it. The development of new therapies often requires...

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Problems solved by technology

"TGF-βrelated mechanisms of bone destruction in multiple myeloma" published in "Bone" (Bone) 48(1): 129-134 in 2011 (transforming growth factor β mechanism associated with bone loss in multiple myeloma ) proposed that TGF-β (inhibition of transforming growth factor β) may become a potential method for the treatment of multiple myeloma bone disease, but the article also pointed out that the treatment is still controversial, and its effectiveness needs further verification

However, there is currently no research work based on mathematical modeling to study the simulation evaluation platform for the treatment of multiple myeloma bone disease

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