Borneol-based macromolecule antibacterial material

A technology of antibacterial materials and polymers, which is applied in the field of new polymer antibacterial materials, can solve problems such as polymer materials that are not mentioned, and achieve the effects of good growth inhibition, huge development potential, and good biocompatibility

Active Publication Date: 2014-06-25
北京市晟名宽科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] None of the above-mentioned prior art mentions the polymer materials prepared by derivat

Method used

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  • Borneol-based macromolecule antibacterial material
  • Borneol-based macromolecule antibacterial material
  • Borneol-based macromolecule antibacterial material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 200 μg of acrylylated L-borneol monomer in a reaction flask, add 200 μL of methanol to provide a solvent environment, then add 10 μL of ammonium persulfate solution with a concentration of 0.1 mg / mL as an initiator, and react at 60 ° C for 4 h. The polymerization method has the advantages of simple operation and high polymerization degree, and the molecular weight of the polymer can reach 250,000.

[0027] attached figure 1 The CD spectrum of the synthesized L-borneol polymer was prepared for Example 1 of the present invention. It can be seen from the CD diagram analysis that the synthesized polymer has optical activity.

Embodiment 2

[0029] Take 200 μg of acrylylated borneol monomer (monomer synthesized by any method in Example 6 to Example 8) into a reaction bottle, add 400 μL of methanol to provide a solvent environment, and then add a concentration of 0.1 mg / mL 20 μL of ammonium persulfate solution was used as an initiator, and the reaction was carried out at 70° C. for 6 h. The molecular weight of the polymer in this polymerization method can reach 530,000.

Embodiment 3

[0031] Take 200 μg of acrylylated borneol monomer (monomer synthesized by any method in Example 6 to Example 8) in a reaction bottle, add 300 μL of methanol to provide a solvent environment, and then add 1.32 mg of azobisiso Butyronitrile was used as an initiator, and the reaction was carried out at 60°C for 4h. The molecular weight of the polymer in this polymerization method can reach 200,000.

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Abstract

The invention relates to a borneol-based macromolecule antibacterial material. According to the macromolecule antibacterial material, four acrylyl-derivative borneol monomers of different chiral configurations are taken as raw materials, and macromolecules are generated by virtue of a polymerization reaction to be taken as the antibacterial material. A chiral macromolecule material has good anti-adhesive and growth-inhibiting effects on gram-positive bacterium, gram-negative bacterium and fungus, also has the characteristics of good biocompatibility and nontoxicity, can be taken as the antibacterial material applied to the fields of medicines, foods, health, and environmental protection and has a huge development potential.

Description

technical field [0001] The invention relates to a borneol-based polymer antibacterial material. It belongs to the field of medical polymer technology and is applicable to the fields of medicine, food, sanitation, and environmental protection. It is a new type of polymer antibacterial material that inhibits the adhesion and growth of microorganisms. Background technique [0002] In recent years, with the increase of bacterial infection cases year by year, the nosocomial infection control of medical devices has attracted more and more attention from people in the field, so it is particularly urgent to prepare environmentally friendly polymer materials with high antibacterial properties. [0003] On the one hand, the atoms of the borneol compound are arranged in a hollow three-dimensional structure to form a polyhedral or polycyclic structure, which is a chiral molecule with a unique structure. The borneol molecule with this unique structure belongs to natural terpenoids, wide...

Claims

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Application Information

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IPC IPC(8): C08F220/16C07C69/54C07C67/14C07C67/08A01N37/04A01P1/00
Inventor 王兴罗玲琼
Owner 北京市晟名宽科技发展有限公司
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