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Preparation method of nano material-based bionic drug-loaded gradient slow release bone scaffold

A nanomaterial and bone scaffold technology is applied in the field of preparation of novel biomimetic drug-loaded graded sustained-release bone scaffolds, which can solve the problems of unreasonable drug-loading methods and high burst release of bone scaffolds, and achieve the goal of promoting osteoblast differentiation and improving the success of bone scaffolds. rate effect

Inactive Publication Date: 2014-07-09
SHANGHAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The unreasonable drug loading method of the bone scaffold makes the drug accumulate on the surface of the bone scaffold, resulting in a higher burst release

Method used

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  • Preparation method of nano material-based bionic drug-loaded gradient slow release bone scaffold
  • Preparation method of nano material-based bionic drug-loaded gradient slow release bone scaffold
  • Preparation method of nano material-based bionic drug-loaded gradient slow release bone scaffold

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Embodiment Construction

[0026] The present invention is described below through specific examples, and is described in detail as follows in conjunction with the accompanying drawings:

[0027] like figure 1 As shown, a preparation method based on nanomaterial bionic drug-loaded gradient sustained-release bone scaffold, the process steps are as follows:

[0028] 1) Design and manufacture of negative type a and negative type b

[0029] Using CATIA V5R19 (France, Dassault System) to design two negative types, namely negative type a and negative type b. The negative type consists of three components, the base, the left half ring, and the right half ring. Among them, the bottom of the negative type b has a groove, which is convenient for the vertical loading of the icicles and avoids the situation of the icicles falling. Negative components are manufactured by means of fusion deposition molding technology, the negative 3D solid model is saved in STL format, imported into the fusion deposition mo...

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Abstract

The invention discloses a preparation method of a nano material-based bionic drug-loaded gradient slow release bone scaffold. The preparation method comprises following steps: preparation of a negative die; preparation of a slurry; preparation of an inner layer drug-loaded bone scaffold; preparation of an outer layer drug-loaded bone scaffold; packaging; and the like. The nano material-based bionic drug-loaded gradient slow release bone scaffold is capable of satisfying requirements of common bone scaffolds on porosity, strength, and surface morphology; bone scaffold drug-loading diversity is achieved; gradient slow release of loaded drugs is realized; success rate of complex bone defect treatment in clinic is increased effectively; and application prospect in clinic is promising.

Description

technical field [0001] The invention provides a preparation method of a novel biomimetic drug-carrying graded slow-release bone scaffold, in particular a preparation method of a nano-material biomimetic drug-carrying graded slow-release bone scaffold. Background technique [0002] At present, in clinical bone defect repair methods, tissue engineering technology and bionic bone made of biomaterials are one of the best alternatives to autologous bone transplantation in solving the problem of insufficient bone source. [0003] Melt accumulation molding technology is one of the additive manufacturing technologies. The technology is to heat and melt thermoplastic polymer materials into filaments, and accumulate them on the molding surface for molding. The molding speed and precision are high, and it can be used to make molds with complex internal structures. Biomanufacturing is the intersection of manufacturing science, life science and material science, and the engineered manufa...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/50A61L27/54
Inventor 高海涛林柳兰董洋洋陆宇杰胡庆夕
Owner SHANGHAI UNIV