Cabazitaxel acetic acid compound and crystal thereof
A technology of cabazitaxel and acetic acid compound, applied in the field of crystallization, can solve the problems that the solvate is not stable enough, the preparation method is complicated, and the industrialization cost is high, and the invention is suitable for industrial-scale preparation, the preparation process is simple, and the stability is good. Effect
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Embodiment 1
[0035] Cabazitaxel (2 g) was dissolved in 20 ml of acetic acid, and 30 ml of purified water was added dropwise with stirring at room temperature, a solid was precipitated, stirred for 1 h, filtered with suction, the solid was washed with purified water, and dried in vacuum (40°C) for about 3 hours to obtain 1.9 g white solid. The mass percentage of acetic acid in the product was determined by gas chromatography to be 4.85%.
Embodiment 2
[0037] Cabazitaxel (2 g) was dissolved in 10 ml of acetic acid, 15 ml of purified water was added dropwise with stirring at room temperature, a solid was precipitated, stirred for 1 h, filtered with suction, the solid was washed with purified water, and dried in vacuum (40°C) for about 3 hours to obtain 1.92 g white solid. The mass percentage of acetic acid in the product was determined by gas chromatography to be 2.87%.
Embodiment 3
[0039] Cabazitaxel (2 g) was dissolved in 30 ml of acetic acid, and 45 ml of purified water was added dropwise with stirring at room temperature, a solid was precipitated, stirred for 1 h, filtered with suction, the solid was washed with purified water, and dried in vacuum (40°C) for about 3 hours to obtain 1.85 g white solid. The mass percentage of acetic acid in the product was determined by gas chromatography to be 3.95%.
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Abstract
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