Nerve repairing material and preparation method thereof

A nerve repair and nerve growth technology, applied in the field of nerve repair materials, can solve problems such as reduced effectiveness, insufficient donors, complex nerve repair mechanism, etc., to increase the probability of prognosis, increase biological activity, and improve the effect of repair

Active Publication Date: 2014-07-23
RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although there are many studies on various nerve growth or trophic factors, there is always a "bottleneck" problem in the practical application of such nerve growth or trophic factors: small molecules are rapidly degraded in the body, making many nerve growth or trophic factors unavailable. Degraded or inactivated before it can do its job, greatly reducing its effectiveness
In addition, the nerve repair mechani

Method used

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  • Nerve repairing material and preparation method thereof
  • Nerve repairing material and preparation method thereof
  • Nerve repairing material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of nerve growth factor / basic fibroblast growth factor / carrier slow-release system

[0048] (1) The combination of nerve growth factor and basic fibroblast growth factor is used as component I, and a solution containing fibrinogen, fibronectin, heparin and fibrin stabilizing factor is prepared as component II;

[0049] (2) preparing a solution containing thrombin and calcium chloride as component III;

[0050] (3) Add component II to component I to dissolve component I;

[0051] (4) Add component III to the mixed solution of components II and I to form nerve growth factor / basic fibroblast growth factor / carrier sustained release system

[0052] (5) The concentration of the fibrinogen in the above step (1) in the component II may be 4 mg / ml. The concentration of thrombin in the component III in the step (2) may be 40 IU / ml, and the concentration of the calcium chloride in the component III may be 35 μmol / ml. The pH value of said component II and component II...

Embodiment 2

[0055] Preparation of Multichannel Nerve Repair Conduit Containing Nerve Growth Factor / Vascular Endothelial Cell Growth Factor / Carrier Sustained Release System

[0056] (1) The combination of nerve growth factor and vascular endothelial cell growth factor is used as component I, and a solution containing fibrinogen, fibronectin, heparin and fibrin stabilizing factor is prepared as component II;

[0057] (2) preparing a solution containing thrombin and calcium chloride as component III;

[0058] (3) Add component II to component I to dissolve component I;

[0059](4) Component III is added to the mixed solution of components II and I to form nerve growth factor / vascular endothelial cell growth factor / carrier sustained release system;

[0060] (5) Inject the nerve growth factor / vascular endothelial cell growth factor / carrier slow-release system into the chitosan nerve guide, and prepare a multi-channel nerve guide with mold and freeze-drying technology;

[0061] (6) The concen...

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Abstract

The invention discloses a nerve repairing material and a preparation method thereof. The nerve repairing material comprises a combination of cell factors capable of promoting nerve growth, and a controlled-release carrier of the cell factors, wherein the carrier is mainly composed of fibrinogen, fibronectin, heparin, fibrin stabilizing factor, thrombin and calcium chloride, wherein the combination of the cell factors capable of promoting nerve growth is optimally at least two of nerve growth factor, brain-derived neurotrophic factor, basic fibroblast growth factor and vascular endothelial cell growth factor, and is embedded in the carrier. According to the nerve repairing material, the speed of releasing cell factors can be regulated according to the nerve repairing progress by utilizing 'intelligent release' of the controlled-release carrier, so that the functions of cell factors can be progressively played; furthermore, the nerve repairing can be further promoted by utilizing the synergy of the cell factors.

Description

technical field [0001] The present application relates to a nerve repair material, in particular to a high-efficiency nerve repair material utilizing the synergistic effect and slow release system of various cytokines capable of promoting nerve growth. Background technique [0002] In our country, more than 1 million patients suffer from peripheral nerve injury due to various traumas or surgical operations (such as tumor resection) every year. If these patients do not receive timely and effective repair treatment, it will cause permanent loss of nerve function in relevant parts. The hypertrophic scar tissue in the nerve gap during nerve injury is the main obstacle to the self-repair of peripheral nerves. Peripheral nerve injuries with large gaps need to be repaired by autologous nerve transplantation; however, there are many disadvantages in autologous nerve transplantation, such as nerve disorders in the donor area, formation of neuromas in the donor area, limited nerves i...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/16A61K38/19A61K47/42A61K47/36A61K47/04A61P25/00
Inventor 敖强刘伟强王臻
Owner RESEARCH INSTITUTE OF TSINGHUA UNIVERSITY IN SHENZHEN
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