Nerve repairing material and preparation method thereof

Abstract

The invention discloses a nerve repairing material and a preparation method thereof. The nerve repairing material comprises a combination of cell factors capable of promoting nerve growth, and a controlled-release carrier of the cell factors, wherein the carrier is mainly composed of fibrinogen, fibronectin, heparin, fibrin stabilizing factor, thrombin and calcium chloride, wherein the combination of the cell factors capable of promoting nerve growth is optimally at least two of nerve growth factor, brain-derived neurotrophic factor, basic fibroblast growth factor and vascular endothelial cell growth factor, and is embedded in the carrier. According to the nerve repairing material, the speed of releasing cell factors can be regulated according to the nerve repairing progress by utilizing 'intelligent release' of the controlled-release carrier, so that the functions of cell factors can be progressively played; furthermore, the nerve repairing can be further promoted by utilizing the synergy of the cell factors.

Description

technical field [0001] The present application relates to a nerve repair material, in particular to a high-efficiency nerve repair material utilizing the synergistic effect and slow release system of various cytokines capable of promoting nerve growth. Background technique [0002] In our country, more than 1 million patients suffer from peripheral nerve injury due to various traumas or surgical operations (such as tumor resection) every year. If these patients do not receive timely and effective repair treatment, it will cause permanent loss of nerve function in relevant parts. The hypertrophic scar tissue in the nerve gap during nerve injury is the main obstacle to the self-repair of peripheral nerves. Peripheral nerve injuries with large gaps need to be repaired by autologous nerve transplantation; however, there are many disadvantages in autologous nerve transplantation, such as nerve disorders in the donor area, formation of neuromas in the donor area, limited nerves i...

AI Technical Summary

Problems solved by technology

[0004] Although there are many studies on various nerve growth or trophic factors, there is always a "bottleneck" problem in the practical application of such nerve growth or trophic factors: small molecules are rapidly degraded in the body, making many nerve growth or trophic factors unavailable. Degraded or inactivated before it can do its job, greatly reducing its effectiveness

In addition, the nerve repair mechanism is complex, and the microenvironment after nerve injury has various effects on nerve repair. Therefore, although there are many theories, there is no theory that can fully explain the entire repair process. Except for autologous transplantation, there is no good theory. However, autologous transplantation obviously has the defect of a serious shortage of donors, and there are various limitations in its application.

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