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Feed for laboratory rats and mice and preparation method thereof

A technology for experimental rats and feed, applied in animal feed, animal feed, molding or processing of animal feed, etc., can solve problems such as inactivation, difficulty in quantifying food intake of experimental mice, and difficulty in quantifying intake

Inactive Publication Date: 2014-07-30
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pellet feed will cause damage or inactivation of certain vitamins, biological enzymes or other active ingredients or special added ingredients during the pressing process, so it is not suitable for processing some special feeds or feeds that require the addition of some special active ingredients, or It is difficult to process into pellets at all, such as high-fat feed, some feeds that need to add special nutrients or drugs, etc.
At the same time, due to its suitable hardness, pellet feed is suitable for eating by mice and mice, but the waste of feed in the process of gnawing is large and it is difficult to quantify the food intake of experimental mice, so it is difficult to quantify the effect of experimental mice on the added ingredients or drugs in the feed. intake
Therefore, it is necessary to carry out special processing and improvement to the existing pellet feed, and to invent a feed form that is conducive to quantitative large and mouse feed intake, and is used to quantitatively feed special substances to rats or mice by way of ingestion Or drugs to improve the adverse effects of long-term gavage and injection commonly used on experimental mice

Method used

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  • Feed for laboratory rats and mice and preparation method thereof
  • Feed for laboratory rats and mice and preparation method thereof
  • Feed for laboratory rats and mice and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Take SPF grade female and male juvenile Wistar rats, 6 each, and raise them in a single cage. ① Feed the standard pellet feed (20g / animal), take out the remaining feed after 24 hours, and eat the feed powder that fell into the cage, weigh them separately, and calculate the daily amount of pellet feed consumed by the animal; ② Feed the animals with different specifications Capsule feed (15 capsules each of 0#, 1# and 2#), collect the remaining capsules after 24 hours, clear out the feed in the capsules, collect the powdered feed that fell into the cage, weigh them separately, and calculate the daily intake Amount of capsule feed.

[0044] The daily food intake of young female and male Wistar rats to capsule diet was greater than that of pellet diet ( P <0.01); the selectivity of rats to different specifications of capsule feed was equivalent; the amount of discarded feed during feeding was less than that of pellet feed.

Embodiment 2

[0046] Take 6 SPF grade female and 6 male adult Wistar rats respectively, and the implementation steps are the same as in Example 1.

[0047] Adult female and male Wistar rats had a slightly higher daily intake of capsule feed than pellet feed, and had similar selectivity to different specifications of capsule feed; the amount of discarded feed during feeding was less than that of pellet feed.

Embodiment 3

[0049] Get 6 SPF grade female and 6 male aged Wistar rats respectively, feed amount: pellet feed 40g / rat, capsule feed 0#, 1# and 2# capsules 25 / rat each. All the other steps are the same as in Embodiment 1.

[0050] The daily feed intake of aged female and male Wistar rats was slightly larger than that of pelleted feed, and their selectivity to capsules of different specifications was similar; the amount of discarded feed during feeding was less than that of pelleted feed.

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Abstract

The invention provides a feed for laboratory rats and mice. The feed is obtained by feeding a feed into capsules. The feed is mainly applied in the following ways: 1. processing special feeds which are difficultly processed into standard granulated feeds such as high-fat diets and special-formula feeds; 2. processing feeds added with certain unstable or special active substances to prevent inactivation of active substances during processing of conventional feeds; 3. feeding animals with certain special substances or medicaments in the form of feed for a long time in animal experiments to ensure quantitative taking of animals and avoid hurting experimental animals caused by long-time gavage or injection; and (4) performing microencapsulation on certain additives / medicaments which have special smell or are unstable and tend to be inactivated in combination with a microencapsulation technology and feeding into feeds for feeding to ensure the palatability and the quantitative taking of feeds.

Description

Technical field [0001] The invention is the field of animal feed technology, which involves a feed for experimental rats and mice. Background technique [0002] The feed in the process of experimental animal breeding is mainly divided into breeding feed and breeding feed. The physical traits of the feed processing can be divided into: powder feed, granular feed, granular materials, puffed feed, baked feed, gelatin feed, liquid feed, Canned feed.At present, the feeds that are generally used by mice and mice are granular feed.The advantages of granular feed are large density, small volume, and good taste, which can increase the amount of animal feeding, avoid picky eaters, and ensure the full price of the feed and the needs of animal growth and development.However, the granular feed will cause some vitamins, biological enzymes or other active ingredients or special additives in the process of suppression processing.It is difficult to process particles at all, such as high -fat feed...

Claims

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Application Information

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IPC IPC(8): A23K1/18A23K1/14A23K1/10A23K1/16A23K40/10A23K50/50
Inventor 席晓霞席栋宾魏虎来白德成李廷保田永刚张景科
Owner LANZHOU UNIVERSITY
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