Dynamic mechanical experimental device and method for tissue engineering scaffold

Abstract

The invention discloses a dynamic mechanical experimental device and a dynamic mechanical experimental method for a tissue engineering scaffold. The device comprises a pressure sensor, a reciprocating motor, a cyclic dynamic stress loading component and an assembling bracket used for placing the reciprocating motor and the cyclic dynamic stress loading component, wherein the pressure sensor comprises a sensing gasket and display equipment; the sensing gasket is arranged between the reciprocating motor and the cyclic dynamic stress loading component, and the sensing gasket and the display equipment are connected with the reciprocating motor; the cyclic dynamic stress loading component comprises a lower bracket used for transmitting driving force upwards, a spring used for transmitting dynamic force, an upper bracket used for transmitting pressure stress downwards, an ejector pin used for transmitting the stress to an experimental material, and a positioning porous cover used for fixing the ejector pin and an experimental porous plate. According to the device and method, a simulation experiment in tissue engineering scaffolds of different sizes under cyclic stress environmental loading under the frequency of 1-150Hz can be met, multi-group experiments can be simultaneously performed, and the experimental efficiency is improved.

Description

technical field [0001] The invention relates to an experimental device of mechanics and cell biology, in particular to a dynamic mechanical experimental device and method of a tissue engineering support, which belongs to the field of medical devices. Background technique [0002] The in vivo environment of organisms is a cyclic and dynamic environment. However, in the past, the mechanical performance characterization, simulated in vivo degradation, biomimetic mineralization and cell co-culture of tissue engineering scaffold materials were mostly limited to static experiments. There is a lack of research on the performance characterization of tissue engineering scaffolds in biomedical applications under pathological conditions. [0003] Experiments such as simulated in vivo fatigue, degradation, and cell co-culture of tissue engineering scaffolds under dynamic mechanical loads are the key points in the field of performance research involved in the bionic preparation of tissue...

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Problems solved by technology

[0004] At present, many devices and methods for dynamic stress loading culture are aimed at the mechanical environment of cells and mostly adopt separate cell culture under stress stimulation or perfusion bioreactors. However, the impact of dynamic mechanical stimulation on tissue engineering scaffolds is not considered. Effects of this force-bearing body during simulated in vivo degradation, biomimetic mineralization, and cell co-culture

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