Preparation method of biodegradable nasal hemostatic sponge

A technology of hemostatic sponge and nasal cavity, which is applied in medical science, absorbent pads, bandages, etc., to achieve the effects of low production cost, easy-to-obtain raw materials, and simple and easy operation steps

Active Publication Date: 2014-09-10
SAIKE SAISI BIOTECH CO LTD
View PDF2 Cites 29 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the problems such as the long reaction time and the large amount of catalyst used in the synthesis of the fourth generation of degradable and expandable nasal hemostatic materials in the above prior art, the present invention provides A preparation method of a degradable hemostatic sponge for nasal cavity with shortened reaction time, reduced catalyst consumption and reduced production cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of biodegradable nasal hemostatic sponge
  • Preparation method of biodegradable nasal hemostatic sponge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Synthesis of chain extender: Take 90g of hexamethylene diisocyanate (HDI) and place it in a reaction bottle, and make the molar ratio to HDI (n BDO : n HDI = 1:14) of 1,4-butanediol (BDO) was slowly added dropwise to HDI, stirred and reacted at 80°C for 3 hours, the reaction system was cooled to room temperature, and purified by adding n-hexane to obtain a chain extender, which was characterized by NMR The product has been purified;

[0041](2) Synthesis of block prepolymer: put PEG 600 / L-lactide / caprolactone by mass (35g / 25g / 25g) in a reaction flask, add 200 μL of catalyst stannous octoate, and heat to 140°C under vacuum , reacted for 24 hours to obtain the desired block prepolymer;

[0042] (3) Synthesis of biomedical polyurethane: Dissolve 25g of the chain extender prepared in step (1) with DMSO, and the molar ratio to the block prepolymer is 1:1, after the block prepolymer in step (2) is prepared , remove the vacuum, maintain normal pressure, and lower the te...

Embodiment 2

[0045] (1) (2) Synthesize chain extender and block prepolymer according to the method in Example 1;

[0046] (3) Synthesis of biomedical polyurethane: Dissolve 2.8g of hexamethylene diisocyanate (HDI) and 17.6g of the prepared chain extender in DMSO, the molar ratio between the two is 0.4: 1, the molar number of the two The molar ratio of the sum to the block prepolymer is 1:1, and it is ready for use; after the block prepolymer is prepared, remove the vacuum, maintain normal pressure, and cool the reaction system to 80°C, slowly dissolve the dissolved DMSO solution Add it dropwise into the block prepolymer system, stir, and react for 2.5 hours. The reaction system becomes viscous. Dilute it with an appropriate amount of DMSO, and then repeatedly settle with water and ethanol to obtain the required polybiomedical polyurethane.

[0047] (3) Preparation of hemostatic sponge: Dissolve 5g of the biomedical polyurethane synthesized above into 1,4-dioxane to form 100g of a 5% soluti...

Embodiment 3

[0049] (1) (2) Synthesize chain extender and block prepolymer according to the method in Example 1;

[0050] (3) Synthesis of biomedical polyurethane: Dissolve 4.3g of hexamethylene diisocyanate (HDI) and 13.7g of the prepared chain extender in DMSO, the molar ratio between the two is 0.8: 1, the molar number of the two The molar ratio of the sum to the block prepolymer is 1:1, and it is ready for use; after the block prepolymer is prepared, remove the vacuum, maintain normal pressure, and cool the reaction system to 80°C, slowly dissolve the dissolved DMSO solution Add it dropwise into the block prepolymer system, stir, and react for 2 hours. The reaction system becomes viscous. Dilute it with an appropriate amount of DMSO, and then repeatedly settle with water and ethanol to obtain the desired biomedical polyurethane.

[0051] (4) Preparation of hemostatic sponge: Dissolve 6g of the biomedical polyurethane synthesized above into 1,4-dioxane to form 100g of a 6% solution, add...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to the technical field of biodegradable absorbable hemostasis materials, and in particular relates to a preparation method of a biodegradable nasal hemostatic sponge suitable for hemostasis of a postoperative nasal cavity in a filling manner. The method comprises the following steps: (1) synthesizing a chain extender; (2) synthesizing a block prepolymer; (3) synthesizing biomedical polyurethane, namely mixing the chain extender and an ethyl isocyanate solution in a dissolving manner and dropwise adding the mixture into the block prepolymer so as to synthesize the biomedical polyurethane; (4) preparing the hemostatic sponge. In the step of synthesizing the biomedical polyurethane, the chain extender and the ethyl isocyanate solution are physically mixed and then react with the block prepolymer, so that the synthetic reaction time of the polymer is shortened; the adding amount of stannous octoate taken as a catalyst is reduced; the energy consumption is decreased; the reaction cost is lowered. Thus, the biodegradable nasal hemostatic sponge is favorable for industrial production; the method is simple and practical.

Description

technical field [0001] The invention relates to the technical field of degradable absorbable hemostatic materials, in particular to a preparation method of a degradable nasal cavity hemostatic sponge suitable for stuffing and hemostasis after nasal cavity surgery. Background technique [0002] Nasal cavity surgery is a very common surgery in China and even in the world. Due to the small scope of nasal cavity surgery, the local blood vessels are rich, easy to bleed, and the position is deep, it cannot be sutured to stop bleeding after surgery, and it must rely on packing to stop bleeding. Nasal packing is an important measure to prevent bleeding, adhesion or restenosis after sinonasal surgery. The purpose of tamponade is to reduce the pain of patients as much as possible while ensuring the effect, so the choice of postoperative tamponade has long been the focus of attention. [0003] In most cases, hospitals are using non-degradable wound dressings, which have many disadva...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08L75/06C08G18/66C08G63/664C08G63/85A61L15/26A61L15/62A61L15/44
Inventor 刘常琳祝金凤侯昭升
Owner SAIKE SAISI BIOTECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap