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Iron-based smectite dispersible tablets and preparation method thereof

A technology of iron-based montmorillonite and dispersible tablets, which is applied in the direction of medical preparations of non-effective ingredients, pharmaceutical formulas, inorganic non-effective ingredients, etc., can solve the problems that iron-based montmorillonite dispersible tablets have not yet been developed, and achieve improvement Oxidative stability, improved disintegration speed, and reduced production costs

Inactive Publication Date: 2014-09-24
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the obvious advantages of the above-mentioned iron-based montmorillonite in the treatment of chronic renal failure and iron-deficiency anemia, it was found through Chinese patent retrieval that iron-based montmorillonite dispersible tablets have not yet been developed

Method used

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  • Iron-based smectite dispersible tablets and preparation method thereof
  • Iron-based smectite dispersible tablets and preparation method thereof
  • Iron-based smectite dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The iron-based montmorillonite dispersible tablet consists of a plain tablet and a coating, wherein the plain tablet is composed of the following components by weight:

[0049]

[0050] Made into 1000 pieces, each piece contains 0.0074g of ferrous ion

[0051] Described coating is sugar coating;

[0052] The weight percent of iron ion in the described iron-based montmorillonite is 5%

[0053] (1) Take the iron-based montmorillonite and corresponding auxiliary materials of measured portions, and pulverize them through a 100-mesh sieve for subsequent use;

[0054] (2) Get the iron-based montmorillonite powder that step (1) obtains, add the ethanol of 150ml70%, 30g starch and 6.0g sodium carboxymethyl starch, stir and make soft material, cross 20 mesh sieves and make wet granules;

[0055] (3) Dry the wet granules prepared in step (2) at 50°C, pass through a 18-mesh sieve for granulation, add 6.0g sodium carboxymethyl starch, 0.06g vitamin C, 0.06g L-malic acid, 0.06g...

Embodiment 2

[0058] The iron-based montmorillonite dispersible tablet consists of a plain tablet and a coating, wherein the plain tablet is composed of the following components by weight:

[0059]

[0060] Made into 1000 pieces, each piece contains 0.009g of ferrous ion

[0061] The weight percent of iron ion in the described iron-based montmorillonite is 6%

[0062] (1) Take the iron-based montmorillonite and corresponding auxiliary materials of measured portions, and pulverize them through a 100-mesh sieve for subsequent use;

[0063] (2) Get the iron-based montmorillonite powder that step (1) obtains, add the ethanol of 150ml70%, 30g starch and 6.0g sodium carboxymethyl starch, stir and make soft material, cross 20 mesh sieves and make wet granules;

[0064] (3) Dry the wet granules prepared in step (2) at 50°C, sieve through a 18-mesh sieve, add 6.0g sodium carboxymethyl starch, 0.06g vitamin C, 0.06g L-malic acid, 0.06 Mix homogeneously after 1g xylitol, 105g microcrystalline cel...

Embodiment 3

[0073] The preparation formula of the present invention is made up of following components:

[0074]

[0075] Made into 1000 pieces, each piece contains 0.0105g of ferrous ion

[0076] The weight percent of iron ion in the described iron-based montmorillonite is 7%

[0077] (1) Take the iron-based montmorillonite and corresponding auxiliary materials of measured portions, and pulverize them through a 100-mesh sieve for subsequent use;

[0078] (2) Get the iron-based montmorillonite powder that step (1) obtains, add the ethanol of 150ml70%, 30g starch and 6.0g sodium carboxymethyl starch, stir and make soft material, cross 20 mesh sieves and make wet granules;

[0079] (3) Dry the wet granules prepared in step (2) at 50°C, sieve through a 18-mesh sieve, add 6.0g sodium carboxymethyl starch, 0.06g vitamin C, 0.06g L-malic acid, 0.06 Mix homogeneously after 1g xylitol, 105g microcrystalline cellulose and 1.5g magnesium stearate, and compress to obtain iron-based montmorillon...

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Abstract

The invention discloses iron-based smectite dispersible tablets and a preparation method thereof, and relates to a medicinal preparation of the iron-based smectite. The iron-based smectite dispersible tablets are composed of an iron-based smectite medicine and accessories mainly including a filler, a disintegrant, a lubricant and a binder; in addition, an antioxidant is added to achieve an anti-oxidization effect. The preparation method of the tablets comprises the steps of mixing the pretreated iron-based smectite with the accessories in a certain ratio, forming the mixture into dispersible tablets by virtue of wet granulation and tabletting, and covering the dispersible tablets with sugar coatings. The iron-based smectite dispersible tablets are used for treating chronic renal failure hyperphosphatemia and iron-deficiency anemia. The iron-based smectite dispersible tablets are high in disintegration rate, and capable of quickly bonding with phosphates and effectively preventing the incidence of hyperphosphatemia.

Description

technical field [0001] The invention relates to a pharmaceutical preparation of iron-based montmorillonite, in particular to an iron-based montmorillonite dispersible tablet and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] In recent years, with the continuous deepening of research on chronic renal failure in traditional Chinese medicine and western medicine, some important research results have been obtained. In the long-term treatment of chronic renal failure and a large number of practical observations, traditional Chinese medicine has formed a unique treatment idea - special prescription treatment for specific diseases, and has done a large number of controlled experiments and statistical analysis to illustrate its effectiveness. Traditional Chinese medicine has a certain therapeutic effect on chronic renal failure, but its curative effect on patients with end-stage renal failure is not satisfactory. The goal ...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K9/36A61K47/26A61K47/02A61K47/22A61K47/12A61P7/06A61P3/12
Inventor 乔敏刘钢李红新秦大伟牛夏邵兰兰孟震晓
Owner SHANDONG SBOND PHARMA
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