A skin antibacterial pharmaceutical composition and its preparation method and application

The technology of an antibacterial drug and a composition is applied in the field of medicine, and can solve the problems of dilation, stretch marks, hirsutism, glucocorticoid-induced acne, bacterial infection, purpura, cataract, menstrual cycle disorder, and unsatisfactory treatment effect, etc. To achieve the effect of inhibiting the reproduction of pathogens, reducing the irritation of the drug, and improving the therapeutic effect of the drug

Active Publication Date: 2015-08-19
湖南知达医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(7) Others: tranilast, glycyrrhizic acid, and multivitamins can be used in the treatment of dermatitis and eczema, and interferon-γ can be used as an adjuvant therapy. It may be effective in the treatment of dermatitis and eczema, but often requires long-term maintenance medication
The above treatment methods are many, but all have their limitations and adverse reactions, such as long-term external use of glucocorticoids can cause certain skin adverse reactions (such as skin atrophy, telangiectasia, stretch marks, hirsutism, glucocorticoid acne, bacterial Infection, purpura, etc.), long-term large-scale topical or oral administration can cause systemic adverse reactions (iatrogenic adrenal insufficiency, Cushing's syndrome, psychoneurological symptoms, glaucoma, cataract, and menstrual cycle disorders, etc.)
[0008] Due to the complex causes of dermatitis eczema and skin fungal infection and disease, although there are many treatment methods, they all have their limitations and adverse reactions, and the treatment effect is not very good. ideal

Method used

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  • A skin antibacterial pharmaceutical composition and its preparation method and application
  • A skin antibacterial pharmaceutical composition and its preparation method and application
  • A skin antibacterial pharmaceutical composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 Skin antibacterial drug composition gel of the present invention

[0023] A gel for skin antibacterial drug composition, the active ingredients include 1.5% benzoic acid, 1% salicylic acid, 2.25% clove oil, and 0.5% borneol.

[0024] Its specific preparation method comprises the following steps: Accurately weigh each drug component of the prescription amount, add 15g of benzoic acid and 10g of salicylic acid into 960 ml of purified water, and fully dissolve them with a high-speed disperser; simultaneously mix 22.5g of clove oil and 5g of borneol is fully dispersed in 50ml of propylene glycol, after the dispersion is uniform, add it to the above-mentioned fully dissolved solution, continue to stir to mix evenly, the pH value of the solution is between 5.0 and 6.0, and the product becomes gelatinous; finally add humectant and The pH regulator can be made into a finished product.

Embodiment 2

[0025] Embodiment 2 skin antibacterial drug composition gel of the present invention

[0026] A gel for skin antibacterial drug composition, active ingredients include 1.5% benzoic acid, 1% salicylic acid, 2.25% clove oil, 0.5% borneol, 0.3% baicalin, 0.3% honeysuckle extract, hydrochloric acid Cetirizine 0.5%; Sodium chloride 1%.

[0027] The specific preparation method is: accurately weigh each drug component of the prescription amount, add 15g of benzoic acid, 10g of salicylic acid, 3g of baicalin, and 10g of sodium chloride into 960 ml of purified water, and fully dissolve it with a high-speed disperser; Fully disperse 22.5g of clove oil and 5g of borneol in 50ml of propylene glycol, disperse evenly, add to the above-mentioned fully dissolved solution, continue stirring to mix evenly, the pH value of the solution is between 5.0 and 6.0, and the product becomes gel ;Finally, sterile filter the aqueous solution of cetirizine hydrochloride and the aqueous solution of ...

Embodiment 3

[0029] Example 3 Skin antibacterial drug composition ointment of the present invention

[0030]

[0031] Preparation process: add carbomer 940 to the aqueous solution containing salicylic acid to form a low-viscosity acidic solution, stir to dissolve the salicylic acid completely, add benzoic acid, clove oil, borneol, polysorbate-80 and a small amount of Glycerol and water, stir to dissolve, mix well, then add ethylparaben and adjust the pH value to 6.0 with triethanolamine.

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PUM

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Abstract

The invention relates to a skin antibacterial medicine composition as well as a preparation method and an application thereof, and belongs to the technical field of medicines. The composition is prepared from the following materials by weight percent: 1% to 3% of benzoic acid, 1% to 3% of salicylic acid, 0.5% to 5% of clove oil and 0.5% to 2% of borneol. The antibacterial and itching-resistant effects of the composition can be further enhanced after 0.3% of baicalin, 0.3% of honeysuckle extract, 0.5% of cetirizine hydrochloride and 1% of sodium chloride are added into the composition. The pharmacodynamic test proves that the composition provided by the invention has good effects for treating eczemas and fungal skin diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a skin antibacterial drug composition, a preparation method and application thereof. Background technique [0002] As we all know, dermatitis and eczema skin diseases are common diseases in dermatology. The etiology and pathogenesis of dermatitis and eczema are not yet clear. The etiology is quite complicated, and most of them are caused by allergies. It is an allergic reaction caused by the interaction of various internal and external factors. Eczema belongs to a kind of delayed allergic reaction, and mast cells play a key role in the pathogenesis. On the one hand, mast cell degranulation causes the classic immediate allergic reaction, and on the other hand, it releases eosinophils, chemokines, leukotrienes and their arachidonic acid derivatives, etc. The infiltration of polymorphonuclear cells was caused at the site of the original degranulation cells; 24-48 hours...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/61A61P17/00A61P17/04A61P31/10A61P31/04A61K31/60A61K31/045A61K31/7048A61K31/495A61K33/14
Inventor 卞国良郭真赵振伟
Owner 湖南知达医药科技有限公司
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