Preparation method of polylactic acid hemodialysis membrane with zwitterionic surface

Abstract

The invention discloses a preparation method of a polylactic acid hemodialysis membrane with a zwitterionic surface. The method comprises the following steps: soaking the polylactic acid hemodialysis membrane into a dopamine solution so as to generate a poly-dopamine modified polylactic acid hemodialysis membrane in a nascent state; taking out the membrane, then placing the membrane into deionized water for oscillation washing, and drying in vacuum so as to obtain a dry poly-dopamine modified polylactic acid hemodialysis membrane; soaking the membrane into an organic solvent for 0.5 to 2 hours, and then adding triethylamine and 2-bromine butyryl bromine for reaction for 6 to 24 hours so as to obtain a polylactic acid hemodialysis membrane with 2-bromine butyryl bromine fixed on the surface; and soaking the membrane into a mixed solution, adding nitrogen, zwitterion, an initiator and ligand for reaction for 1 to 24 hours, then taking out the membrane, washing with water and ethanol in sequence, and performing vacuum drying. The membrane prepared by the preparation method disclosed by the invention has the advantages that the hydrophilia is obviously improved, the blood penetration resistance is reduced, an ultrafiltrate coefficient is obviously increased, the biocompatibility of the membrane is improved, and the side effects of hemodialysis are reduced.

Description

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AI Technical Summary

Benefits of technology

This technology allows for creating a thin film that can be attached onto various surfaces like medical devices or biological materials by forming strong bonds between molecules called atoms. These layers help improve their ability to transmit chemicals effectively without losing its effectiveness over longer periods due to water vapor transmission through them.

Problems solved by technology

This patent describes different ways to make biomolecule membrances like those made up of natural macroswitchings and chemically crosslinked microporous resin films. These techniques aim to solve issues associated with traditional hydrogels due to low solubility, weak binding affinity towards various compounds, difficulty in manufacturing them, and potential negative side effects caused by excessive blood clotting. To address these challenges, research focuses on developing novel polymer compositions containing specific components that enhance the performance of existing medical devices.