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A dual-mode imaging nanomicelle and its preparation method and use

A dual-mode imaging and nano-micelle technology, which is applied in the field of biomedical imaging, can solve the problems of complex preparation methods, unclear action duration of dual-mode imaging probes, optimal imaging time, high toxicity of bismuth sulfide, etc., and achieve high sensitivity , reduced fluorescence quenching, and high spatial resolution

Active Publication Date: 2016-10-26
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the bismuth sulfide used in this patent is highly toxic, and the preparation method is complicated, and the duration of action of the dual-mode imaging probe and the optimal imaging time of the two modes are not clear

Method used

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  • A dual-mode imaging nanomicelle and its preparation method and use
  • A dual-mode imaging nanomicelle and its preparation method and use
  • A dual-mode imaging nanomicelle and its preparation method and use

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Embodiment 1

[0039] Microscopic morphology observation of dual-mode imaging nanomicelles of the present invention:

[0040]Electron microscope scanning is carried out to the dual-mode imaging nanomicelle prepared by the present invention, see figure 1 , it can be seen that the dual-mode imaging nanomicelles are spherical particles with a diameter of about 80 nm.

Embodiment 2

[0042] The dual-mode imaging nanomicelle of the present invention is prepared by the following method:

[0043] CT imaging agent, NPAPF and PLGA-PEG are dissolved in chloroform according to the mass ratio of 1:1:8;

[0044] The obtained chloroform solution was mixed with 10 times the volume of deionized water, and the organic solvent chloroform was removed to obtain the dual-mode imaging nanomicelle.

Embodiment 3

[0046] The dual-mode imaging nanomicelle of the present invention is prepared by the following method:

[0047] Dissolve CT imaging agent: NPAPF: DSPE-PEG in chloroform according to the mass ratio of 1:1:8;

[0048] The obtained chloroform solution was mixed with 10 times the volume of deionized water, and the organic solvent chloroform was removed to obtain the dual-mode imaging nanomicelle.

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Abstract

The invention discloses dual-mode imaging nano-micelle which comprises a CT (Computed tomography) contrast medium, red fluorescent molecules NPAPF (N-(2-naphthyl)phenylamino)phenyl)-fumaronitrile) and a carrying material for carrying the CT contrast medium and the NPAPF into the dual-mode imaging nano-micelle. The invention further discloses a preparation method and an application of the dual-mode imaging nano-micelle. The dual-mode imaging nano-micelle combines fluorescent imaging and CT imaging, achieves targeted dual-mode imaging of living tumor and organs and meanwhile is long in action time, intensive in detection signal and very small in toxicity.

Description

technical field [0001] The invention belongs to the field of biomedical imaging, and relates to a nanomicelle and its preparation method and application, more specifically to a dual-mode imaging nanomicelle, its preparation method and application, which combines fluorescence imaging and CT imaging , to achieve in vivo targeting and imaging of animals. Background technique [0002] Malignant tumors are one of the most important diseases that endanger human health. According to the data released by the International Union Against Cancer, in 2008, 12.7 million people worldwide suffered from cancer and 7.6 million died. If effective measures are not taken, it is estimated that by 2030, there will be 26 million new cancer cases every year. Whether in the world or in China, cancer has become the first cause of death for human beings. Therefore, the development of effective cancer imaging diagnostic agents is of great significance to the promotion of Chinese people's health. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K49/04
Inventor 梁兴杰张吉梅安菲菲李婵李鸿基王东亮张旭霍帅东金叔宾姜永刚
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA